Abstract | OBJECTIVE: Summarize the current knowledge about oxidative stress-related organ dysfunction in inflammatory and septic conditions, and its potential prevention and treatment by antioxidants in critically ill patients, focusing on naturally occurring antioxidants and clinical trials. STUDY SELECTION: PubMed, MEDLINE, and personal database search. SYNTHESIS: CONCLUSIONS: Three antioxidant nutrients have demonstrated clinical benefits and reached level A evidence: a) selenium improves clinical outcome ( infections, organ failure); b) glutamine reduces infectious complication in large-sized trials; and c) the association of eicosapentaenoic acid and micronutrients has significant anti-inflammatory effects. Other antioxidants are still on the clinical benchmark level, awaiting well-designed clinical trials.
|
Authors | Mette M Berger, René L Chioléro |
Journal | Critical care medicine
(Crit Care Med)
Vol. 35
Issue 9 Suppl
Pg. S584-90
(Sep 2007)
ISSN: 0090-3493 [Print] United States |
PMID | 17713413
(Publication Type: Journal Article, Review)
|
Chemical References |
- Antioxidants
- Biomarkers
- Glutamine
- Eicosapentaenoic Acid
- Selenium
|
Topics |
- Animals
- Antioxidants
(administration & dosage, analysis, therapeutic use)
- Biomarkers
- Clinical Trials as Topic
- Dose-Response Relationship, Drug
- Eicosapentaenoic Acid
(therapeutic use)
- Glutamine
(therapeutic use)
- Humans
- Oxidative Stress
- Selenium
(therapeutic use)
- Sepsis
(drug therapy, metabolism)
- Systemic Inflammatory Response Syndrome
(drug therapy, metabolism)
|