Effects of sulodexide on hemostatic factors, lipid profile, and inflammation in chronic peritoneal dialysis patients.

Abstract

Sulodexide, a standardized extractive glycosaminoglycan containing 80% "fast moving" heparin and 20% dermatan sulfate, decreased plasma D-dimer, a marker of intravascular coagulation, and fibrinogen levels in chronic peritoneal dialysis patients. Blood levels of von Willebrand factor, lipid, and high-sensitivity C-reactive protein were not significantly changed. No bleeding episodes were reported. These results suggest that sulodexide was effective in partially reversing the thrombogenic coagulation profile without increasing the risk of bleeding.

• Authors: Soon Bae Kim, Su Hee Kim, Moo Song Lee, Jai Won Chang, Sang Koo Lee, Jung Sik Park
• Journal: Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis (Perit Dial Int) 2007 Jul-Aug Vol. 27 Issue 4 Pg. 456-60 ISSN: 0896-8608 [Print] United States
• PMID: 17602156 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Anticoagulants
• Biomarkers
• Glycosaminoglycans
• Lipids
• von Willebrand Factor
• glucuronyl glucosamine glycan sulfate
• C-Reactive Protein

Topics

• Anticoagulants (pharmacology)
• Biomarkers (blood)
• C-Reactive Protein (metabolism)
• Disseminated Intravascular Coagulation (blood, etiology, prevention & control)
• Enzyme-Linked Immunosorbent Assay
• Female
• Follow-Up Studies
• Glycosaminoglycans (pharmacology)
• Hemostasis (drug effects)
• Humans
• Kidney Failure, Chronic (blood, therapy)
• Lipids (blood)
• Male
• Middle Aged
• Nephelometry and Turbidimetry
• Peritoneal Dialysis, Continuous Ambulatory (adverse effects)
• Prospective Studies
• Treatment Outcome
• von Willebrand Factor (metabolism)