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glucuronyl glucosamine glycan sulfate (Vessel)

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Also Known As:

Vessel; sulodexide; Luzone; 3-glucosaminoglycan sulfate; Aterina; Sigma-Tau brand of glucuronyl glucosamine glycan sulfate; Tedec Meiji brand of glucuronyl glucosamine glycan sulfate; Vessel (polysaccharide); glucuronyl glucosaminoglycan sulfate; glucuronylglucosaminoglycan sulfate

Networked: 33718 relevant articles (948 outcomes, 2329 trials/studies)

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Bio-Agent Context: Research Results

Carbohydrates: 4088
- Polysaccharides: 2929
  - Glycosaminoglycans: 2808
    - glucuronyl glucosamine glycan sulfate: 33718

Experts

1.	Serruys, Patrick W: 140 articles (12/2015 - 02/2002)
2.	Stone, Gregg W: 135 articles (01/2016 - 01/2002)
3.	Mehran, Roxana: 87 articles (01/2016 - 01/2002)
4.	Colombo, Antonio: 69 articles (12/2015 - 02/2002)
5.	Waksman, Ron: 64 articles (12/2015 - 01/2002)
6.	Windecker, Stephan: 59 articles (10/2015 - 05/2002)
7.	Xu, Bo: 58 articles (12/2015 - 09/2005)
8.	Lansky, Alexandra J: 57 articles (07/2015 - 01/2002)
9.	Dichgans, Martin: 56 articles (08/2015 - 01/2002)
10.	Park, Seung-Jung: 54 articles (10/2015 - 04/2003)

Related Diseases

1.	Neoplasms (Cancer) 08/01/2014 - "Tumor-associated neovasculature is a critical therapeutic target; however, despite significant progress made in the clinical efficacy of anti-vessel drugs, the effect of these agents remains transient: over time, most patients develop resistance, which inevitably leads to tumor progression. " 01/01/2012 - "Compared to untreated (Ctrl) tumors, an improved and highly functional vascularization was detected in androgen-deprived (AD) tumors, reflected by increases in DCE MRI parameters and by increased number of vessels (VN), vessel density (VD), and vessel area fraction (VF) from qIHC. " 05/01/2002 - "When comparing several combinations of vessel characteristics, a combination of any two major characteristics demonstrated the best results (sensitivity, 94% [33 of 39 tumors]; specificity, 93% [three of 45 tumors]). " 07/01/1983 - "DSA was most helpful in demonstrating the presence or absence of major vessel involvement by tumor when this could not be ascertained definitely on CT. " 01/01/2011 - "Since detailed information of tumor progression in response to therapy is important to assess the efficacy of anti-tumor treatment in vivo, noninvasive imaging techniques emerge more and more as important tools to monitor alterations in tumor growth and vessel recruitment, as well as metastatic spread over time. "
2.	Pathologic Constriction (Stenosis) 01/01/1987 - "To establish the most meaningful scoring system, we developed the grading of stenosis which is "critical" or significant in the single-, double-, and triple-vessel method (SDT), and the extent of improvement in the predictive value which may be induced by accounting for the predominance of the three major coronary arteries nourishing the left ventricle. " 05/01/1981 - "In the successfully dilated stenoses or occlusions there was a highly significant increase in the vessel diameter, with a highly significant reduction in the pressure gradient across the stenosis. " 08/01/1979 - "The best results can be expected in patients with single-vessel disease, with a short history of angina (less than 1 year), and with narrow, noncalcified proximal stenosis. " 03/01/1992 - "However, in cases of good collateral circulation, no case showed a complete defect when the target vessel had improved to less than 75% of stenosis. " 03/01/1992 - "In 16 cases of poor collateral circulation, six cases showed a complete defect, although the target vessel had improved to less than 75% of stenosis. "
3.	Thrombosis (Thrombus) 07/01/2014 - "There is controversy concerning the most effective treatment of portal vein thrombosis, which is based on information that is seldom robust and whose primary objective is to achieve a return to vessel patency. " 09/01/2012 - "The best treatment for patients with Behçet's disease (BD) with major vessel thrombosis has not been fully determined. " 04/01/2013 - "The diameter and flow volume in the largest collateral vessel at the time of thrombus detection were significantly smaller in the improved patients than the others. " 11/15/1996 - "At 90 minutes, patients with TIMI grade 2 flow had greater infarct vessel narrowing and a significantly greater incidence of thrombus than patients with TIMI grade 3 flow. " 07/10/1992 - "Evaluation of 21h and representative analogues in vivo using a rabbit model of small vessel thrombosis revealed significantly greater antithrombotic efficacy compared to that of previously studied compounds with similar intrinsic biological activity measured in vitro but inferior aqueous solubility."
4.	Stroke (Strokes) 04/01/2013 - "The ReFlow (Mechanical Recanalization With Flow Restoration in Acute Ischemic Stroke) study shows that mechanical recanalization with flow restoration is highly effective in stroke patients with a large intracranial vessel occlusion presenting within 4.5 h after symptom onset. " 08/01/1996 - "Small-vessel strokes had the best outcome. " 03/12/2015 - "Among patients with acute ischemic stroke with a proximal vessel occlusion, a small infarct core, and moderate-to-good collateral circulation, rapid endovascular treatment improved functional outcomes and reduced mortality. " 08/01/2014 - "In a derivation cohort of anterior circulation large vessel occlusion stroke patients treated with endovascular therapy within 8 hours from time last seen well (n=247), we performed logistic regression to identify independent predictors of good outcome (90-day modified Rankin Scale, 0-2). " 06/17/2014 - "Our findings suggest that the Penumbra system might be effective for treatment in elderly patients or patients with high NIHSS score wherein rt-PA therapy is inadvisable or ineffective in ischemic stroke secondary to large vessel occlusion. "
5.	Myocardial Infarction 06/01/2012 - "Excellent target vessel recanalization (Thrombolysis in Myocardial Infarction score of 3) and good outcome at 90 days (modified Rankin Score ≤ 2) were more common in younger patients (45% versus 14%, P = .047, and 41% versus 0%, P = .008, respectively). " 05/01/2009 - "All the treated vessels (100%) were successfully re-canalized, Trials In Myocardial Infarction (TIMI) score of 3. At 90-day follow-up, of the 5 patients treated, 2 had modified Rankin score (mRS) of < 2. This small series shows the safety and efficacy of the Penumbra System in the thrombolysis of large vessel occlusive disease." 05/01/1993 - "Different thrombolytic regimens for acute myocardial infarction proved to be equally effective in large scale mortality trials despite significant differences in their efficacy with respect to early infarct-related vessel patency as shown in smaller angiographic trials. " 12/01/2010 - "In this patient-level pooled analysis, EES compared with PES resulted in a significant and persistent reduction in target vessel failure and major adverse cardiac events at 3 years due to fewer myocardial infarction and ischemic target lesion revascularization events, which is consistent with superior safety and efficacy of the EES platform." 12/01/2009 - "The use of Endeavor versus Driver was associated with a significant reduction in target vessel revascularization through 4-year follow-up with no difference in death, nonfatal myocardial infarction, quality-adjusted survival, or total medical costs. "

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4.	bevacizumab
5.	Phenobarbital (Luminal)
6.	Sirolimus (Rapamycin)
7.	Oxygen
8.	Cholesterol
9.	Carbon Monoxide
10.	Calcium

Related Therapies and Procedures

1.	Stents
2.	Angioplasty (Angioplasty, Transluminal)
3.	Transplants (Transplant)
4.	Thrombectomy
5.	Catheters