Gyrate atrophy of the choroid and retina with hyper-ornithinemia responsive to vitamin B6: a case report.

Abstract

BACKGROUND:

Gyrate atrophy of the retina and choroid is a rare autosomal recessive inherited disease, characterized by progressive chorioretinal atrophy that results in progressive deterioration of peripheral and night vision and leading to blindness.

CASE PRESENTATION:

This report presents a case of a 28-year-old man consulting for a progressive fall of visual acuity with hemeralopia. Eye fundoscopy showed regions of confluent rounded chorioretinal atrophy. The visual field and retinal angiography were altered. A high level of plasma ornithine (629 nmol/mL) was detected and a diagnosis of gyrate atrophy of the retina and choroid was made. The patient was treated with high dose Pyridoxine supplement (300 mg/d for 6 months) and the ornithine level of his serum was successfully reduced.

CONCLUSION:

The exact mechanism of chorioretinal atrophy in hyper-ornithinemia is not known and a small percentage of the affected people respond to Vitamin B6 supplementation.

• Authors: Alireza Javadzadeh, Davood Gharabaghi
• Journal: Journal of medical case reports (J Med Case Rep) Vol. 1 Pg. 27 (Jun 12 2007) ISSN: 1752-1947 [Print] England
• PMID: 17565677 (Publication Type: Journal Article)