PON1, a new biomarker of cardiovascular disease, is low in patients with systemic vasculitis.

Abstract

OBJECTIVES:

Because systemic vasculitis (SV) predisposes to atherosclerosis, and high-density lipoprotein (HDL) prevents atherosclerosis by "reverse cholesterol transport" and by inhibiting low-density lipoprotein (LDL) oxidation thanks to apolipoprotein A-I (Apo-AI) and paraoxonase 1 (PON1), we assessed whether LDL oxidation was increased in SV and associated with less PON1 activity.

METHODS:

The sera of 33 patients with active SV (ASV), 32 in full remission of SV (RSV) and 20 healthy subjects (HS) were analyzed for C-reactive protein (CRP), high-sensitivity-CRP, lipids, lipoproteins, apolipoproteins, PON1 activity, LDL-immune complexes (LDL-IC), and auto-antibodies to oxidized-LDL (ox-LDL), and anticardiolipin antibodies.

RESULTS:

CRP was higher in ASV than RSV and HS, and negatively correlated with HDL-cholesterol and Apo-AI. Autoantibodies to ox-LDL and highly oxidized malondialdehyde-LDL were higher in RSV than ASV and HS (P<0.05). LDL-IC titers were higher in ASV than RSV and HS (P<0.05). PON1 activity was lower in ASV and RSV than HS (P=0.02). A trend toward a negative correlation between basal PON1 activity and anti-MDA-LDL antibodies (P=0.06) was observed.

CONCLUSION:

Inflammatory markers in SV were associated with a modified lipoprotein profile, which could lower PON1 activity and contribute to increased ox-LDL titers and accelerated atherosclerosis development.

• Authors: Thomas Quéméneur, Françoise Martin-Nizard, Abdelmejid Kandoussi, Xavier Kyndt, Philippe Vanhille, Eric Hachulla, Pierre-Yves Hatron, Jean-Charles Fruchart, Patrick Duriez, Marc Lambert
• Journal: Seminars in arthritis and rheumatism (Semin Arthritis Rheum) Vol. 37 Issue 3 Pg. 149-55 (Dec 2007) ISSN: 0049-0172 [Print] United States
• PMID: 17512573 (Publication Type: Journal Article)

Chemical References

• Apolipoprotein A-I
• Autoantibodies
• Biomarkers
• Cholesterol, HDL
• Lipoproteins, LDL
• malondialdehyde-low density lipoprotein, mouse
• oxidized low density lipoprotein
• Malondialdehyde
• C-Reactive Protein
• Aryldialkylphosphatase
• PON1 protein, human

Topics

• Aged
• Apolipoprotein A-I (blood)
• Aryldialkylphosphatase (blood)
• Atherosclerosis (blood, immunology)
• Autoantibodies (blood)
• Biomarkers (blood)
• C-Reactive Protein (metabolism)
• Cholesterol, HDL (blood)
• Female
• Humans
• Lipoproteins, LDL (blood, immunology, metabolism)
• Male
• Malondialdehyde (analogs & derivatives, blood, immunology)
• Middle Aged
• Oxidative Stress
• Vasculitis (blood, immunology)