Abstract | BACKGROUND & OBJECTIVE: METHODS: A total of 22 malignant tumor patients suffered from severe mucositis caused by high dose chemotherapy combined AHSCT. The analgesic degree before and after treatment was evaluated by the scores of Visual Analogue Scale (VAS) (range 0-10). The median VAS scores of all patients were above 4 (moderate to severe pain) before the administration of transdermal fentanyl. The quality of life before and after treatment was evaluated by the Standard of Quality of Life drew up in China in 1990. The adverse events after treatment were evaluated by Common Toxicity Criteria formulated by National Cancer Institute of the USA. RESULTS: The median VAS score has been decreased from baseline at 6 (4-9) to 3.5 (0-9) on Day 3, 2 (0-6) on Day 5, 0.5 (0-8) on Day 7, 0 (0-6) on Day 10, and 0 (0-5) on Day 15 after treatment (P<0.001). The overall response rate was 100%, while the complete response rate was 45.5%. The quality of life of the patients was improved significantly (P<0.01). The adverse events after treatment of transdermal fentanyl included dizziness, somnolence, dysuria, mild and transient nausea, vomiting, discomfort of stomach, and so on. All the adverse events disappeared within several days after proper managements. Neither severe adverse event nor drug addiction was found. CONCLUSIONS: Transdermal fentanyl has good analgesic effect on painful severe mucositis induced by AHSCT. It is convenient and well tolerated, and could improve quality of life significantly.
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Authors | Hui-Qiang Huang, Qing-Qing Cai, Xu-Bin Lin, Bu-Fei Wang, Qing Bu, Yan Gao, Yu-Long Peng |
Journal | Ai zheng = Aizheng = Chinese journal of cancer
(Ai Zheng)
Vol. 26
Issue 4
Pg. 390-3
(Apr 2007)
China |
PMID | 17430658
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Analgesics, Opioid
- Cytarabine
- Podophyllotoxin
- Melphalan
- Carmustine
- Fentanyl
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Topics |
- Administration, Cutaneous
- Adolescent
- Adult
- Analgesics, Opioid
(administration & dosage, therapeutic use)
- Antineoplastic Combined Chemotherapy Protocols
(adverse effects, therapeutic use)
- Carmustine
(adverse effects, therapeutic use)
- Child
- Child, Preschool
- Combined Modality Therapy
- Cytarabine
(adverse effects, therapeutic use)
- Female
- Fentanyl
(administration & dosage, therapeutic use)
- Hematopoietic Stem Cell Transplantation
(adverse effects)
- Humans
- Lymphoma, Non-Hodgkin
(therapy)
- Male
- Melphalan
(adverse effects, therapeutic use)
- Middle Aged
- Mucositis
(drug therapy, etiology)
- Pain
(drug therapy, etiology)
- Pain Measurement
- Podophyllotoxin
(adverse effects, therapeutic use)
- Quality of Life
- Transplantation, Homologous
(adverse effects)
- Young Adult
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