Abstract | BACKGROUND: METHODS: All renal transplant recipients at our outpatient clinic with a functioning graft for more than one year were invited to participate. We excluded diabetic recipients. Recipient, donor, and transplant characteristics were collected as putative determinants. We used fasting insulin, homeostasis model assessment index, and McAuley's index as valid estimates of insulin resistance. Linear regression models were created to investigate independent determinants of all indexes. RESULTS: A total of 483 recipients (57% male, 50+/-12 years) were analyzed at a median (interquartile range) time of 6.0 (2.6-11.6) years posttransplant. The most consistent determinants across all three indices were body mass index (P<0.001), waist-to-hip ratio (P<0.001), and prednisolone dose (P<0.05). Independent associations were present for total cholesterol (P<0.001), high-density lipoprotein cholesterol (P<0.001), creatinine clearance (P<0.05), recipient age (P<0.001), and gender (P< or =0.002). No independent associations were present for transplant-related factors such as acute rejection treatment or cytomegalovirus seropositivity. CONCLUSIONS:
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Authors | Leendert H Oterdoom, Aiko P J de Vries, Ron T Gansevoort, Willem J van Son, Jaap J Homan van der Heide, Rutger J Ploeg, Paul E de Jong, Reinold O B Gans, Stephan J L Bakker |
Journal | Transplantation
(Transplantation)
Vol. 83
Issue 1
Pg. 29-35
(Jan 15 2007)
ISSN: 0041-1337 [Print] United States |
PMID | 17220787
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Aged
- Body Composition
- Body Mass Index
- Cardiovascular Diseases
(epidemiology)
- Exercise
- Female
- Follow-Up Studies
- Humans
- Insulin Resistance
- Kidney Transplantation
(physiology)
- Life Style
- Male
- Middle Aged
- Obesity
(epidemiology, physiopathology)
- Prednisolone
(adverse effects, therapeutic use)
- Time Factors
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