Abstract | BACKGROUND:
B-type natriuretic peptide (BNP) and N-terminal proBNP ( NT-proBNP) are frequently used in diagnosing and monitoring patients with heart failure. Recent studies have demonstrated that concentrations of these peptides are decreased in obese patients, but whether lower natriuretic peptide concentrations are really due to different hemodynamics is unknown. The relationship between these markers and left ventricular end diastolic pressure (LVEDP) in obesity has not been elucidated. METHODS: We examined patients undergoing cardiac catheterization who had creatinine of < 2.0, no evidence of myocardial infarction or pulmonary embolism, and no cardiac transplant. Body mass index and LVEDP were determined, and BNP and NT-proBNP obtained at the start of each case. Obesity was defined as body mass index of > or = 30 kg/m2. RESULTS: CONCLUSIONS: Obese patients have reduced concentrations of BNP and NT-proBNP compared to nonobese patients despite having elevated LVEDP. This suggests that factors other than cardiac status impact on BNP and NT-proBNP concentrations. The poor relationship between natriuretic peptide concentrations and LVEDP also suggests that these concentrations should not be considered surrogates for cardiac filling pressures or volumes.
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Authors | Jennifer A Taylor, Robert H Christenson, Krishnamurti Rao, Melinda Jorge, Stephen S Gottlieb |
Journal | American heart journal
(Am Heart J)
Vol. 152
Issue 6
Pg. 1071-6
(Dec 2006)
ISSN: 1097-6744 [Electronic] United States |
PMID | 17161055
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Peptide Fragments
- pro-brain natriuretic peptide (1-76)
- Natriuretic Peptide, Brain
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Topics |
- Aged
- Blood Pressure
- Female
- Humans
- Linear Models
- Male
- Middle Aged
- Natriuretic Peptide, Brain
(blood)
- Obesity
(blood, physiopathology)
- Osmolar Concentration
- Peptide Fragments
(blood)
- Regression Analysis
- Ventricular Function, Left
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