Abstract | BACKGROUND: METHODS: We monitored cellular and molecular inflammatory markers in lungs of cystic fibrosis mutant mice homozygous for the DeltaF508 mutation and their littermate controls, either in baseline conditions or after induction of acute inflammation by intratracheal instillation of lipopolysaccharide from Pseudomonas aeruginosa, which would be independent of interactions of bacteria with epithelial cells. The effect of azithromycin pretreatment (10 mg/kg/day) given by oral administration for 4 weeks was evaluated. RESULTS: CONCLUSION:
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Authors | Rachida Legssyer, François Huaux, Jean Lebacq, Monique Delos, Etienne Marbaix, Patrick Lebecque, Dominique Lison, Bob J Scholte, Pierre Wallemacq, Teresinha Leal |
Journal | Respiratory research
(Respir Res)
Vol. 7
Pg. 134
(Oct 25 2006)
ISSN: 1465-993X [Electronic] England |
PMID | 17064416
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents
- Chemokine CXCL2
- Lipopolysaccharides
- Monokines
- Tumor Necrosis Factor-alpha
- cystic fibrosis transmembrane conductance regulator delta F508
- Cystic Fibrosis Transmembrane Conductance Regulator
- Interleukin-10
- Azithromycin
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Topics |
- Animals
- Anti-Inflammatory Agents
(pharmacology)
- Azithromycin
(pharmacology)
- Chemokine CXCL2
- Cystic Fibrosis
(complications, genetics)
- Cystic Fibrosis Transmembrane Conductance Regulator
(genetics)
- Interleukin-10
(biosynthesis)
- Lipopolysaccharides
- Lung
(drug effects, pathology)
- Macrophages
(drug effects, pathology)
- Mice
- Mice, Mutant Strains
- Monokines
(metabolism)
- Neutrophil Infiltration
(drug effects)
- Pneumonia
(chemically induced, etiology, metabolism, pathology)
- Tumor Necrosis Factor-alpha
(metabolism)
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