Abstract | CONTEXT: OBJECTIVE: METHODS: RESULTS:
Hyperinsulinemia increased rate of appearance of 9,12,12-[2H]3 - cortisol (19.3 +/- 0.8 vs. 16.7 +/- 1.1 nmol/min with saline, P < 0.001), indicating increased whole-body 11HSD1. Within adipose, the predominant reaction was reductase conversion of cortisone to cortisol (after 3.5 h of saline infusion, reaching 11.0 +/- 2.7% per hour reductase vs. 5.2 +/- 1.3 dehydrogenase, P < 0.02); insulin increased reductase (reaching 15.8 +/- 3.0, P < 0.05) and tended to increase dehydrogenase activity. Intralipid infusion had no effects on whole-body deuterated cortisol metabolism, but increased both dehydrogenase and reductase (reaching 16.7 +/- 1.8, P < 0.01) activities in adipose. CONCLUSIONS:
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Authors | Deborah J Wake, Natalie Z M Homer, Ruth Andrew, Brian R Walker |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 91
Issue 11
Pg. 4682-8
(Nov 2006)
ISSN: 0021-972X [Print] United States |
PMID | 16954164
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Blood Glucose
- Fat Emulsions, Intravenous
- Insulin
- Deuterium
- 11-beta-Hydroxysteroid Dehydrogenase Type 1
- Hydrocortisone
|
Topics |
- 11-beta-Hydroxysteroid Dehydrogenase Type 1
(metabolism)
- Adipose Tissue
(enzymology)
- Adult
- Aged
- Blood Glucose
(analysis)
- Cross-Over Studies
- Deuterium
(pharmacokinetics)
- Fat Emulsions, Intravenous
(pharmacology)
- Gene Expression Regulation, Enzymologic
- Humans
- Hydrocortisone
(metabolism)
- Infusion Pumps
- Insulin
(blood, pharmacology)
- Male
- Microdialysis
(methods)
- Middle Aged
- Single-Blind Method
- Whole-Body Counting
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