Abstract | AIM: METHODS: Twenty type 2 diabetic patients treated with diet only underwent a 3-h OGTT for measurement of plasma glucose, insulin, proinsulin, C-peptide and cAMs before and after administration of randomly given M (n = 9; 1700 mg/day) or T (n = 11; 600 mg/day). After 16 weeks of treatment, a second OGTT was performed. Insulin sensitivity was calculated with homeostasis model assessment and with oral glucose insulin sensitivity (OGIS), which quantifies dynamic glucose clearance per unit change of insulin. Insulin secretion was assessed by modelling technique. Differences in these parameters before and after treatment, as well as possible relationships with cAMs, were assessed. RESULTS: Basal and stimulated plasma glucose decreased after therapy in both the groups by approximately 20%. Basal insulin resistance also decreased. Insulin sensitivity in dynamic conditions (OGIS: ml/min/m(2)) increased with M (289.3 +/- 18.8 vs. 234.7 +/- 18.1, p < 0.02) and tended to improve with T (323.5 +/- 18.1 vs. 286.8 +/- 22.1, p = 0.09). Total insulin secretion over the OGTT [TIS: nmol/l(3 h)] tended to decrease with M (17.1 +/- 2.5 vs. 27.3 +/- 0.3, p = 0.08) but not with T (23.6 +/- 3.5 vs. 22.5 +/- 2.7). Plasma concentrations of E-Selectin decreased in T (38.0 +/- 2.3 vs. 51.2 +/- 6.1 ng/ml, p < 0.05). No correlation was found between insulin sensitivity and cAMs. CONCLUSIONS: Model-based indices of insulin sensitivity and secretion during an OGTT can be able to detect changes observed in patients under treatment with pharmacological agents such as M or T. Both the drugs improved glucose control similarly. Decreased plasma E-Selectin concentrations were seen in patients on T therapy only.
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Authors | A Kautzky-Willer, A Tura, C Winzer, O F Wagner, B Ludvik, U Hanusch-Enserer, R Prager, G Pacini |
Journal | Diabetes, obesity & metabolism
(Diabetes Obes Metab)
Vol. 8
Issue 5
Pg. 561-7
(Sep 2006)
ISSN: 1462-8902 [Print] England |
PMID | 16918591
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Blood Glucose
- C-Peptide
- Cell Adhesion Molecules
- Chromans
- Hypoglycemic Agents
- Insulin
- Thiazolidinediones
- Proinsulin
- Metformin
- Troglitazone
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Topics |
- Blood Glucose
(metabolism)
- Body Weight
- C-Peptide
(blood)
- Cell Adhesion Molecules
(blood)
- Chromans
(therapeutic use)
- Diabetes Mellitus, Type 2
(blood, drug therapy, physiopathology)
- Drug Monitoring
(methods)
- Female
- Glucose Tolerance Test
(methods)
- Humans
- Hypoglycemic Agents
(therapeutic use)
- Insulin
(blood)
- Insulin Resistance
- Male
- Metformin
(therapeutic use)
- Middle Aged
- Proinsulin
(blood)
- Thiazolidinediones
(therapeutic use)
- Troglitazone
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