Abstract | OBJECTIVE: In males, the pubertal increase in sex hormone production has been associated with proatherogenic changes in lipid and carbohydrate metabolism. Aromatase inhibitors, a novel treatment modality for some growth disorders, may significantly influence these risk factors for cardiovascular disease by suppressing oestrogen biosynthesis and stimulating gonadal androgen production. In the current study, we explored the effects of aromatase inhibition on lipid metabolism, insulin sensitivity, body composition and serum adiponectin in peripubertal boys. DESIGN: Prospective, double-blind, randomised, placebo-controlled clinical study. METHODS: RESULTS: CONCLUSIONS: In males, aromatase inhibition reduces HDL-C and decreases relative FM after the start of puberty. The treatment does not adversely affect insulin sensitivity in lean subjects.
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Authors | Matti Hero, Carina Ankarberg-Lindgren, Marja-Riitta Taskinen, Leo Dunkel |
Journal | European journal of endocrinology
(Eur J Endocrinol)
Vol. 155
Issue 3
Pg. 453-60
(Sep 2006)
ISSN: 0804-4643 [Print] England |
PMID | 16914600
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Apolipoprotein A-I
- Apolipoproteins B
- Aromatase Inhibitors
- Cholesterol, HDL
- Estrogen Antagonists
- Estrogens
- Gonadotropins
- Nitriles
- Triazoles
- Triglycerides
- Letrozole
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Topics |
- Adolescent
- Apolipoprotein A-I
(metabolism)
- Apolipoproteins B
(metabolism)
- Aromatase Inhibitors
(pharmacology)
- Body Composition
(physiology)
- Body Height
(physiology)
- Body Mass Index
- Carbohydrate Metabolism
- Child
- Cholesterol, HDL
(blood)
- Cohort Studies
- Double-Blind Method
- Estrogen Antagonists
(pharmacology)
- Estrogens
(biosynthesis)
- Gonadotropins
(blood, metabolism)
- Humans
- Insulin Resistance
(physiology)
- Letrozole
- Lipid Metabolism
(physiology)
- Male
- Nitriles
(pharmacology)
- Prospective Studies
- Triazoles
(pharmacology)
- Triglycerides
(blood)
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