Abstract | OBJECTIVE: Nonselective inhibition of nitric oxide (NO) with NO synthase antagonists decreases hypotension but worsens outcome clinically. We investigated whether iron (III) complex of diethylenetriaminepentaacetic acid [ DTPA Fe(III)], a scavenger of NO as well as other oxidant mediators, has similar divergent effects in E. coli challenged rats. METHODS: Animals with venous and arterial catheters and challenged with intrabronchial or intravenous E. coli were randomized to treatment with DTPA Fe(III) in doses from 3 to 800 mg/kg or placebo. Mean blood pressure (MBP) was measured in all animals and plasma NO, cytokines, and blood and lung leukocyte and bacteria counts in animals administered intrabronchial E. coli and DTPA Fe(III) 50 mg/kg or placebo. Animals received antibiotics and were observed 168 h. RESULTS: CONCLUSIONS:
DTPA Fe(III) while increasing blood pressure has the potential to worsen outcome in sepsis. Further preclinical testing is required before this agent is applied clinically.
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Authors | Yan Li, Xuemei Li, Michael Haley, Yvonne Fitz, Eric Gerstenberger, Steven M Banks, Peter Q Eichacker, Xizhong Cui |
Journal | Intensive care medicine
(Intensive Care Med)
Vol. 32
Issue 8
Pg. 1263-70
(Aug 2006)
ISSN: 0342-4642 [Print] United States |
PMID | 16775718
(Publication Type: Journal Article)
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Chemical References |
- Cytokines
- Ferric Compounds
- Pentetic Acid
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Topics |
- Animals
- Cytokines
(biosynthesis, drug effects)
- Escherichia coli Infections
(mortality)
- Ferric Compounds
(adverse effects, pharmacology)
- Hypotension
(prevention & control)
- Male
- Pentetic Acid
(adverse effects, pharmacology)
- Rats
- Rats, Sprague-Dawley
- Sepsis
(mortality)
- Survival Rate
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