Abstract | BACKGROUND AND OBJECTIVES:
Gabapentin is an anticonvulsant that has been shown to be effective in the treatment of neuropathic and inflammatory pain in animal and human studies. The analgesic effect of its perioperative use has not been fully elucidated. METHODS: This systematic review (meta-analysis) included 12 randomized controlled trials of 896 patients undergoing a variety of surgical procedures that investigated the impact of perioperative administration of gabapentin on postoperative outcome. RESULTS: The pooled visual analog scores for pain at 4 hours and 24 hours were significantly less in those patients who received gabapentin (weighted mean difference [WMD] = -1.57; 95% confidence interval [CI], -2.14 to -0.99 and WMD = -0.74; CI, -1.03 to -0.45, respectively). A concomitant decrease in opioid usage by those patients who received gabapentin was also noted (odds ratio [OR] = -17.84; CI, -23.50 to -12.18). Gabapentin administration was associated with sedation and anxiolysis (OR = 3.28; CI, 1.21-8.87) but not associated with a difference in lightheadedness, dizziness, nausea, or vomiting. CONCLUSIONS:
|
Authors | Robert W Hurley, Steven P Cohen, Kayode A Williams, Andrew J Rowlingson, Christopher L Wu |
Journal | Regional anesthesia and pain medicine
(Reg Anesth Pain Med)
2006 May-Jun
Vol. 31
Issue 3
Pg. 237-47
ISSN: 1098-7339 [Print] England |
PMID | 16701190
(Publication Type: Journal Article, Meta-Analysis, Systematic Review)
|
Chemical References |
- Amines
- Analgesics
- Cyclohexanecarboxylic Acids
- gamma-Aminobutyric Acid
- Gabapentin
|
Topics |
- Amines
(therapeutic use)
- Analgesics
(therapeutic use)
- Cyclohexanecarboxylic Acids
(therapeutic use)
- Gabapentin
- Humans
- Pain, Postoperative
- Perioperative Care
- Randomized Controlled Trials as Topic
- gamma-Aminobutyric Acid
(therapeutic use)
|