[Hypersensitivity reaction to systemic corticosteroids in a hemodialysis patients].

Abstract

Hypersensitivity reactions are a feared complication of hemodialysis considering their potential for a serious and eventually fatal course. This association could reflect a number of different exposures, including concomitant medications. Like this, systemic steroid-induced hypersensitivity reactions do occur, althought their incidence is extremely rare. A few reactions related to metylprednisolone have been reported in renal transplantation. The diagnosis could be confirmed by the patient history and performing skin testing, oral or parenteral challenge or by the evidence of specific IgE. We report on a 39-year-old woman undergoing dialysis therapy in whom severe bronchospasm was induced by corticosteroids. She has a positive systemic reaction on the oral steroid challenge test. A successful desensitization regimen for safe administration was achieved. The recognition of high-risk subjects and alternative therapeutic approach are critical, mainly in the management of patients while receiving corticosteroids or a renal allograft.

• Authors: A E Sirvent, I Fernández, R Enríquez, J G Alvarez, F Santos Calle, J Samper, M D Arenas, A Reyes
• Journal: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia (Nefrologia) Vol. 26 Issue 1 Pg. 128-31 ( 2006) ISSN: 0211-6995 [Print] Spain
• Vernacular Title: Reacción de hipersensibilidad por corticoides sistémicos en una paciente en hemodiálisis.
• PMID: 16649434 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Adrenal Cortex Hormones
• Dexamethasone
• Aspirin
• Methylprednisolone

Topics

• Adrenal Cortex Hormones (adverse effects)
• Adult
• Anaphylaxis (chemically induced, therapy)
• Aspirin (adverse effects)
• Asthma (complications)
• Bronchial Spasm (chemically induced)
• Desensitization, Immunologic
• Dexamethasone (administration & dosage, adverse effects)
• Female
• Humans
• Hypotension (chemically induced)
• Injections, Intravenous
• Kidney Failure, Chronic (etiology, therapy)
• Methylprednisolone (administration & dosage, adverse effects)
• Polycystic Kidney, Autosomal Dominant (complications)
• Renal Dialysis
• Skin Tests