[Does G8002A polymorphism in endothelin gene have a meaning for other risks at the patients with heart failure?].

Abstract

UNLABELLED:

Objective of the work is to determine the relation of G8002 polymorhism in endothelin 1 gene to the incidence of diabetes mellitus (DM), ischemic disease of lower limbs (ID LL) and myocardial infarction (MI) at the patients with heart failure. METHODICS: There were observed 224 patients, 176 males, 48 females, average age 55 +/- 12 years, NYHA II/III/IV 82/131/11, average EF LK 25 +/- 7 %, diagnosis ischemic heart disease (IHD) 133, dilatation cardiomyopathy (DCMP) 91.

RESULTS:

Patients with IHD had higher incidence of hypertension (p < 0.0007), diabetes mellitus (p < 0.00007) and hyperlipoproteinemy (p < 0.0006) than patients with DCMP. Patients with IHD who experienced MI had a difference in the distribution of G8002A genotypes for endothelin 1 gene: G 0.718 and A 0.282 alleles vs ischemic patients without MI G 0.882 and A 0.118 (p < 0.05) alleles. Ischemic patients with DM had G allele in 0.67 and A 0.33 unlike ischemic patients without DM G allele 0.791 and A 0.209 (p < 0.03). Ischemic patients with synchronous ID LL had G allele in 0.718 and A 0.282 vs ischemic patients without ID LL G allele 0.882 and A 0.118 (p < 0.0004). At the patients with DCMP there was not found a difference in G8002A genotype and the presence of DM or ID LL.

RESULTS:

At the patients with heart failure on the basis of ischemic heart disease there was found a difference in endothelin G8002A genotype distribution depending on other accessory diseases. There was more frequently present an A allele and less present G allele in the ischemic patients with DM, who had experienced MI or ID LL than in the ischemic patients without these diseases. Genotype with A allele is connected with higher risk of all accessory diseases.

• Authors: L Spinarová, J Spinar, A Vasků, O Ludka, J Vitovec, M Goldbergová, P Hude, J Krejcí, H Pavelcíková
• Journal: Vnitrni lekarstvi (Vnitr Lek) Vol. 52 Issue 1 Pg. 34-9 (Jan 2006) ISSN: 0042-773X [Print] Czech Republic
• Vernacular Title: Má polymorfizmus G8002A v genu pro endotelin význam pro dalsí rizika u pacientů se srdecním selháním?
• PMID: 16526196 (Publication Type: English Abstract, Journal Article)

Chemical References

• Endothelin-1

Topics

• Alleles
• Diabetes Mellitus (genetics)
• Endothelin-1 (genetics)
• Female
• Genetic Predisposition to Disease
• Genotype
• Heart Failure (genetics)
• Humans
• Ischemia (genetics)
• Leg (blood supply)
• Male
• Middle Aged
• Myocardial Infarction (genetics)
• Myocardial Ischemia (genetics)
• Polymorphism, Genetic