A role of androgen receptor protein in cell growth of an androgen-independent prostate cancer cell line.

Abstract

Prostate cancer, which develops due to androgen and is initially responsive to androgen deprivation therapy, often comes to acquire androgen deprivation therapy resistance in short order. We investigated the role of androgen receptor (AR) protein in an androgen-independent prostate cancer cell line using AR ligands and AR siRNA. Although the androgen-independent cell line scarcely responded to AR ligands, their growth was attenuated by ablation of AR protein by siRNA.

• Authors: Takashi Furutani, Ken-ichi Takeyama, Hiroshi Koutoku, Saya Ito, Nobuaki Taniguchi, Eriko Suzuki, Masafumi Kudoh, Masayuki Shibasaki, Hisataka Shikama, Shigeaki Kato
• Journal: Bioscience, biotechnology, and biochemistry (Biosci Biotechnol Biochem) Vol. 69 Issue 11 Pg. 2236-9 (Nov 2005) ISSN: 0916-8451 [Print] England
• PMID: 16306710 (Publication Type: Journal Article)

Chemical References

• Androgens
• Ligands
• RNA, Small Interfering
• Receptors, Androgen

Topics

• Androgens (pharmacology)
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Humans
• Ligands
• Male
• Prostatic Neoplasms (pathology)
• RNA, Small Interfering (pharmacology)
• Receptors, Androgen (genetics, physiology)