Abstract | OBJECTIVE: To assess the presence of both genetic and serological markers of coeliac disease in patients with microscopic colitis, and whether there was associated enteropathy. METHODS: RESULTS: Seventeen of 70 (24.3%) healthy controls were DQ2-positive. Twelve of 25 (48%) patients with lymphocytic colitis (P = 0.027 versus controls), and 11 of 34 (32.3%) with collagenous colitis (P = 0.38 versus controls) were DQ2-positive. There were no differences in the frequency of DQ8-positivity. The coeliac serology was positive in one patient. Duodenal biopsies were performed in 23 DQ2-positive and/or DQ8-positive patients. None had villous atrophy (Marsh III lesion) (0%; 95% confidence interval, 0-6.1). A Marsh type I lesion was found in four patients. Three of these patients were put on a gluten-free diet with disappearance of diarrhoea. CONCLUSIONS: The results suggest that there is an association of lymphocytic colitis with HLA-DQ2 genes, which might be relevant in the pathogenesis of this disease. The association of microscopic colitis with Marsh type III coeliac disease seems to be rare, making it unnecessary to routinely screen for coeliac disease in microscopic colitis patients.
|
Authors | Fernando Fernández-Bañares, Maria Esteve, Carme Farré, Antonio Salas, Montserrat Alsina, Jaume Casalots, Jorge Espinós, Montserrat Forné, Josep Maria Viver |
Journal | European journal of gastroenterology & hepatology
(Eur J Gastroenterol Hepatol)
Vol. 17
Issue 12
Pg. 1333-8
(Dec 2005)
ISSN: 0954-691X [Print] England |
PMID | 16292086
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Autoantibodies
- Biomarkers
- Genetic Markers
- HLA-DQ Antigens
- HLA-DQ2 antigen
- HLA-DQ8 antigen
- Immunoglobulin A
- Glutens
|
Topics |
- Aged
- Autoantibodies
(blood)
- Biomarkers
(blood)
- Biopsy
- Celiac Disease
(complications, genetics)
- Colitis, Microscopic
(diet therapy, etiology, genetics, pathology)
- Duodenum
(pathology)
- Female
- Genetic Markers
- Genetic Predisposition to Disease
- Glutens
(administration & dosage)
- HLA-DQ Antigens
(genetics)
- Haplotypes
- Histocompatibility Testing
- Humans
- Immunoglobulin A
(blood)
- Male
- Middle Aged
- Polymerase Chain Reaction
(methods)
- Prospective Studies
|