Abstract |
The adverse side effects of currently available anti-osteoporotic agents warrant the search for compounds with less toxic effects. In this study, we assessed the phytoestrogenic potentiality of whole aqueous extract of black tea (BTE) in a bilaterally oophorectomized rat model (2.5%, 1 ml/100 g body weight/day for 28 days). Although the supplementation was given for 28 days but, sign of revival of copulation period (estrous stage) from non-receptive diestrous stage was first noticed after 21 days of BTE supplementation in bilaterally oophorectomized rats. This was accompanied by a significant increase in serum estradiol level. To test whether this increase in serum estradiol level could have an influence upon the oophorectomy-induced damage of bone, we assessed marker parameters of bone resorption and osteoclastic activity ( tartrate-resistant acid phosphatase), collagen degradation (urinary hydroxyproline), bone loss ( bone ash mineral content) and bone breaking strength (bone density). Results indicated that increase in serum estradiol level after BTE supplementation could significantly diminish oophorectomy-induced decaying changes in bone. This study proposes that aqueous BTE may be assessed as a phytoestrogenic compound for prevention against estrogen deficiency-related osteoporotic damages.
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Authors | Asankur Sekhar Das, Dolan Das, Maitrayee Mukherjee, Sandip Mukherjee, Chandan Mitra |
Journal | Life sciences
(Life Sci)
Vol. 77
Issue 24
Pg. 3049-57
(Oct 28 2005)
ISSN: 0024-3205 [Print] Netherlands |
PMID | 15996685
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Tartrates
- Tea
- Estradiol
- Collagen
- Acid Phosphatase
- Hydroxyproline
- Calcium
- tartaric acid
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Topics |
- Acid Phosphatase
(metabolism)
- Animals
- Bone Density
(drug effects)
- Bone Resorption
(prevention & control)
- Bone and Bones
(pathology)
- Calcium
(metabolism)
- Collagen
(metabolism)
- Dietary Supplements
- Estradiol
(blood)
- Female
- Hydroxyproline
(urine)
- Ovariectomy
- Rats
- Tartrates
(pharmacology)
- Tea
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