Abstract | OBJECTIVE: RESEARCH METHODS AND PROCEDURES: RESULTS: Compared with lean individuals, overweight-obese individuals had significantly higher HDL apoA-I fractional catabolic rate (0.21+/-0.01 vs. 0.33+/-0.01 pools/d; p<0.001) and production rate (PR; 11.3+/-4.4 vs. 15.8+/-2.77 mg/kg per day; p=0.001). In the lean group, HDL apoA-I PR was significantly associated with apoA-I concentration (r=0.455, p=0.004), whereas in the overweight-obese group, both HDL apoA-I fractional catabolic rate (r=-0.396, p=0.050) and HDL apoA-I PR (r=0.399, p=0.048) were significantly associated with apoA-I concentration. After adjustment for fasting insulin or Homeostasis Model Assessment score, HDL apoA-I PR was an independent predictor of apoA-I concentration. DISCUSSION: In overweight-obese subjects, hypercatabolism of apoA-I is paralleled by an increased production of apoA-I, with HDL apoA-I PR being the stronger determinant of apoA-I concentration. This could have therapeutic implications for the management of dyslipidemia in individuals with low plasma HDL-cholesterol.
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Authors | Esther M M Ooi, Gerald F Watts, Maryam S Farvid, Dick C Chan, Michael C Allen, Simon R Zilko, P Hugh R Barrett |
Journal | Obesity research
(Obes Res)
Vol. 13
Issue 6
Pg. 1008-16
(Jun 2005)
ISSN: 1071-7323 [Print] United States |
PMID | 15976143
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Apolipoprotein A-I
- Cholesterol, HDL
- Lipoproteins, HDL
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Topics |
- Adult
- Apolipoprotein A-I
(blood)
- Cholesterol, HDL
(blood)
- Female
- Humans
- Kinetics
- Lipoproteins, HDL
(blood)
- Male
- Middle Aged
- Obesity
(blood)
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