Abstract | BACKGROUND & AIMS: METHODS: Isolated rat ileal segments were pretreated with pharmacologic agents before intraluminal injection of toxin A or LTB4. After 3 hours, the treated segments were removed and inflammation was assessed by luminal fluid accumulation, myeloperoxidase activity, and histology. RESULTS: CONCLUSIONS:
LTB4 mediates the inflammatory effects of toxin A via activation of TRPV1 receptors.
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Authors | Douglas C McVey, Steven R Vigna |
Journal | Gastroenterology
(Gastroenterology)
Vol. 128
Issue 5
Pg. 1306-16
(May 2005)
ISSN: 0016-5085 [Print] United States |
PMID | 15887113
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Bacterial Toxins
- Enterotoxins
- Ion Channels
- TRPV Cation Channels
- Trpv1 protein, rat
- tcdA protein, Clostridium difficile
- Leukotriene B4
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Topics |
- Animals
- Bacterial Toxins
(metabolism, pharmacology)
- Dose-Response Relationship, Drug
- Dose-Response Relationship, Immunologic
- Enterocolitis, Pseudomembranous
(immunology)
- Enterotoxins
(metabolism, pharmacology)
- Ileitis
(immunology)
- In Vitro Techniques
- Ion Channels
(metabolism)
- Leukotriene B4
(immunology, metabolism, pharmacology)
- Male
- Rats
- Rats, Sprague-Dawley
- TRPV Cation Channels
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