No evidence of cross-reactivity of human antibodies to a 33-mer peptide of the alpha-gliadin component of gluten with Bordetella pertussis pertactin.

Abstract

A 33-mer peptide of the alpha-gliadin component of gluten was recently identified as primary initiator of the inflammatory response to gluten in coeliac disease (CD) patients. This proline-glutamine-rich peptide (PG-peptide) is highly homologous to internal sequence of pertactin, an immunogenic protein of Bordetella pertussis. Using enzyme immunoassays, we measured serum antibodies to pertactin and to PG-peptide in 167 Finnish subjects including pertussis vaccine recipients and pertussis patients, CD and non-CD patients and healthy individuals. We found no cross-reactivity between human antibodies to the two different components, suggesting that neither pertussis immunization nor disease contributes to the pathogenesis of CD.

• Authors: Qiushui He, Matti K Viljanen, Ari E Hinkkanen, Heikki Arvilommi, Jussi Mertsola, Markku Viander
• Journal: Vaccine (Vaccine) Vol. 23 Issue 25 Pg. 3336-40 (May 09 2005) ISSN: 0264-410X [Print] Netherlands
• PMID: 15837240 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Bacterial
• Bacterial Outer Membrane Proteins
• Immunoglobulin A
• Immunoglobulin G
• Virulence Factors, Bordetella
• pertactin
• Glutens
• Gliadin

Topics

• Adolescent
• Adult
• Antibodies, Bacterial (analysis, biosynthesis)
• Antibody Specificity
• Bacterial Outer Membrane Proteins (chemistry, immunology)
• Bordetella pertussis (chemistry, immunology)
• Child
• Child, Preschool
• Cross Reactions
• Enzyme-Linked Immunosorbent Assay
• Female
• Finland
• Gliadin (immunology)
• Glutens (immunology)
• Humans
• Immunoglobulin A (analysis, immunology)
• Immunoglobulin G (analysis, immunology)
• Male
• Middle Aged
• Virulence Factors, Bordetella (chemistry, immunology)
• Whooping Cough (immunology)