Anti-inflammatory, analgesic and antipyretic effects of methanol extract from Bauhinia racemosa stem bark in animal models.

Abstract

In this study, the anti-inflammatory, analgesic, and antipyretic effects of 50, 100 and 200 mg/kg body weight of methanol extract obtained from Bauhinia racemosa stem bark, the so-called MEBR, were investigated. The effects of MEBR on the acute and chronic phases of inflammation were studied in carrageenan, dextran and mediators (histamine and serotonin)-induced paw oedema and cotton pellet-induced granuloma, respectively. Analgesic effect of MEBR was evaluated in acetic acid-induced writhing and hotplate tests. Antipyretic activity of MEBR was evaluated by yeast-induced hyperpyrexia in rats. The anti-oedema effect of MEBR was compared with 10 mg/kg of indomethacin orally. In acute phase of inflammation, a maximum inhibition of 44.9, 43.2, 44.8 and 45.9% (P<0.001) was noted at the dose of 200 mg/kg b.w. after 3h of treatment with MEBR in carrageenan, dextran, histamine and serotonin-induced paw oedema, respectively. Administration of MEBR (200 mg/kg b.w.) and indomethacin (10 mg/kg b.w.) significantly (P<0.05) decreased the formation of granuloma tissue induced by cotton pellet method at a rate of 50.4 and 56.2%, respectively. The extract also inhibited peritoneal leukocyte migration in mice. The MEBR also produced significant (P<0.01) analgesic activity in both models. Further, the MEBR potentiated the morphine- and aspirin-induced analgesic in mice. Treatment with MEBR showed a significant (P<0.01) dose-dependent reduction in pyrexia in rats. The results suggest that MEBR possess potent anti-inflammatory, analgesic and antipyretic activity.

• Authors: M Gupta, U K Mazumder, R Sambath Kumar, P Gomathi, Y Rajeshwar, B B Kakoti, V Tamil Selven
• Journal: Journal of ethnopharmacology (J Ethnopharmacol) Vol. 98 Issue 3 Pg. 267-73 (Apr 26 2005) ISSN: 0378-8741 [Print] Ireland
• PMID: 15814258 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Analgesics
• Analgesics, Non-Narcotic
• Anti-Inflammatory Agents
• Plant Extracts
• Methanol

Topics

• Analgesia
• Analgesics (isolation & purification, therapeutic use, toxicity)
• Analgesics, Non-Narcotic (isolation & purification, therapeutic use, toxicity)
• Animals
• Anti-Inflammatory Agents (isolation & purification, therapeutic use, toxicity)
• Bauhinia
• Edema (drug therapy)
• Inflammation (drug therapy)
• Lethal Dose 50
• Male
• Methanol (isolation & purification)
• Mice
• Plant Extracts (therapeutic use, toxicity)
• Rats