Abstract | BACKGROUND: METHODS: Changes in extracellular concentrations of monoamines and their metabolites were investigated in rat striatum by a microdialysis procedure, and the effects of intraperitoneal injections of midazolam (5 mg/kg), propofol (60 mg/kg), and pentobarbital (15 mg/kg) were then examined. To evaluate the behavioral alteration with these agents, the authors used a step-through passive avoidance test. RESULTS:
Midazolam and propofol slightly increased the extracellular concentration of 5-hydroxytryptamine in the striatum, although pentobarbital did not produce any changes. Midazolam and propofol increased the extracellular concentration of 5-hydroxyindoleacetic acid, a metabolite of 5-hydroxytryptamine, with the peak values each 138% and 138% of that in saline-injected animals, respectively. However, pentobarbital decreased the 5-hydroxyindoleacetic acid concentration to 61% of that in the saline group. Administration of midazolam or propofol immediately after the completing the passive avoidance learning reduced step-through latencies after 24 h, although pentobarbital-injected animals maintained a consistent performance. The effects of midazolam and propofol on step-through latencies were completely antagonized by intracerebroventricular administration of spiroxatrine (5 microg), a 5-hydroxytryptamine 1A antagonist, 30 min before training. CONCLUSIONS:
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Authors | Kazunori Semba, Naoto Adachi, Tatsuru Arai |
Journal | Anesthesiology
(Anesthesiology)
Vol. 102
Issue 3
Pg. 616-23
(Mar 2005)
ISSN: 0003-3022 [Print] United States |
PMID | 15731601
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anesthetics, Intravenous
- Serotonin
- Midazolam
- Propofol
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Topics |
- Amnesia
(chemically induced)
- Anesthetics, Intravenous
(pharmacology)
- Animals
- Avoidance Learning
(drug effects)
- Brain
(drug effects, metabolism)
- Male
- Microdialysis
- Midazolam
(pharmacology)
- Propofol
(pharmacology)
- Rats
- Rats, Wistar
- Serotonin
(metabolism)
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