Lack of effect of captopril on the metabolism of an artificial lipid emulsion similar to chylomicrons in hypertensive hypercholesterolemic patients.

Abstract

OBJECTIVE:

To assess the effect of captopril, an angiotensin-converting enzyme inhibitor, on the metabolism of chylomicrons and their remnants and the possible alterations in the concentrations of plasma lipids caused by the drug in hypertensive hypercholesterolemic individuals.

METHODS:

The metabolism of chylomicrons was tested with the method of artificial lipid emulsion of chylomicrons labeled with 3H-cholesteryl oleate. The emulsion was injected intravenously in 10 patients with mild-moderate arterial hypertension before and 45 days after treatment with captopril (50 mg/day). After injection, blood samples were collected during 60 minutes at pre-established time intervals for determining the decay curve, the fractional catabolic rate (FCR in min-1), and the plasma residence time of the artificial lipid emulsion by analyzing different compartments. The plasma concentrations of the lipids were also assessed before and after treatment.

RESULTS:

The fractional catabolic rate (min-1) of the lipid emulsion before and after treatment with captopril (0.012 +/- 0.003 and 0.011 +/- 0.003, respectively; p = 0.85, n.s.) and the plasma residence time of the emulsion (83.3 +/- 20.8 and 90.9 +/- 22.5 min, n.s.) did not change, but the total cholesterol and LDL-C levels decreased by 7% and 10%, respectively (p = 0.02). The concentrations of HDL-C, triglycerides, Lp(a), and apolipoproteins AI and B did not change.

CONCLUSION:

Treatment with captopril, evaluated with the artificial lipid emulsion method, does not cause deleterious changes in the metabolism of chylomicrons and their remnants.

• Authors: Renato J Alves, Jayme Diament, Rosângela F Amâncio, Neusa Forti, Raul C Maranhão
• Journal: Arquivos brasileiros de cardiologia (Arq Bras Cardiol) Vol. 83 Issue 6 Pg. 512-5; 508-11 (Dec 2004) ISSN: 0066-782X [Print] Brazil
• PMID: 15654448 (Publication Type: Journal Article)

Chemical References

• Antihypertensive Agents
• Cholesterol Esters
• Chylomicrons
• Emulsions
• Lipids
• cholesteryl oleate
• Cholesterol
• Captopril

Topics

• Antihypertensive Agents (pharmacology)
• Captopril (pharmacology)
• Cholesterol (blood)
• Cholesterol Esters
• Chylomicrons (blood, metabolism)
• Emulsions
• Female
• Humans
• Hypercholesterolemia (blood, metabolism)
• Hypertension (blood, metabolism)
• Lipids (blood)
• Male
• Middle Aged