Captopril (Capoten)

A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoconstrictor and important regulator of arterial blood pressure. Captopril acts to suppress the RENIN-ANGIOTENSIN SYSTEM and inhibits pressure responses to exogenous angiotensin.

Also Known As:

Networked: 4607 relevant articles (495 outcomes, 761 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Pfeffer, Marc A: 10 articles (07/2009 - 08/2003)
2.	Moulder, John E: 9 articles (09/2014 - 04/2008)
3.	Califf, Robert M: 9 articles (07/2009 - 08/2003)
4.	Velazquez, Eric J: 8 articles (07/2009 - 08/2003)
5.	McMurray, John J V: 8 articles (07/2009 - 11/2003)
6.	Simko, F: 7 articles (01/2013 - 02/2000)
7.	Dickstein, Kenneth: 7 articles (01/2009 - 09/2002)
8.	Fish, Brian L: 6 articles (09/2014 - 12/2009)
9.	Jacobs, Elizabeth R: 6 articles (09/2014 - 12/2009)
10.	Granerus, Göran: 5 articles (01/2015 - 01/2005)

Related Diseases

1.	Hypertension (High Blood Pressure) 01/01/1991 - "The largest and best known study, of 625 white men with mild hypertension, reported that patients given captopril showed a significant improvement after 6 months in general well-being, work performance, and those skills associated with cognitive function. " 02/01/1993 - "Thus, of the drugs tested, captopril appears to be the best option as third drug in hypertension." 10/01/1987 - "The ACE inhibitor captopril was most effective in the control of hypertension. " 01/01/1986 - "These data suggest that captopril is highly effective for blood pressure control and that the neurohormonal responses to the drug probably provide additional benefits for long-term therapy in hypertension." 06/01/1981 - "Captopril was helpful in the management of refractory hypertension in most cases."
2.	Heart Failure 08/01/1996 - "The use of captopril showed important improvement in exercise capacity in patients with heart failure. " 12/01/1985 - "In some of the patients with chronic heart failure, captopril (6.25 mg) induced a marked decrease of the arterial blood pressure. " 04/05/1993 - "Captopril greatly contributes to the successful therapy of the chronic severe heart failure." 03/01/1993 - "A short period of treatment with intravenous captopril may produce a rapid symptomatic improvement in patients with acute or severe heart failure. " 05/01/1992 - "This partial preservation of beta-adrenergic responsiveness was accompanied by a significant reduction in right ventricular weight and lung weight, suggesting that captopril also improved the signs of heart failure. "
3.	Myocardial Infarction 04/01/1993 - "Captopril has a favorable effect on the dysfunctioning myocardium after myocardial infarction inasmuch as the ischemic burden is reduced, the working capacity is increased, dilation of the left ventricle is prevented, and systolic function is improved." 02/15/1996 - "The treatment with captopril after acute myocardial infarction is not only a clinically efficacious treatment, but also cost-effective in patients after acute myocardial infarction." 04/13/1991 - "Thus early treatment with captopril is effective in preventing the ventricular dilatation that can occur after Q wave myocardial infarction." 01/01/1989 - "The just published study of the efficacy of captopril in preventing the progression of left ventricular dilatation in patients with a recent anterior, transmural myocardial infarction supports this view. " 08/01/2009 - "1. Recently, we demonstrated that oral captopril treatment improved diastolic function and attenuated cardiac remodelling after myocardial infarction (MI) in rats. "
4.	Proteinuria 03/01/2003 - "After 3 days of captopril therapy, the nephrotic-range proteinuria significantly improved. " 09/01/1990 - "We evaluated the efficacy of an ACE inhibitor captopril (CAP) for the reduction of proteinuria in glomerular diseases, and tried to find the conditions in which urinary protein excretion was significantly decreased by this drug. " 12/01/1994 - "Remission of nephrotic-range proteinuria was defined as follows: (1) Onset of the remission was taken as the date when proteinuria was first noted to be < or = 1.0 g/24 hr. (2) The reduction in proteinuria had to be sustained for a minimum of six months and until the end of the Captopril Study. " 01/01/1990 - "Our results demonstrate that captopril is effective in reducing proteinuria in patients with primary glomerular disease with normal renal function. " 12/01/1994 - "Remission of nephrotic-range proteinuria occurred in 7 of 42 patients assigned to captopril (16.7%, mean follow-up 3.4 +/- 0.8 years) and in 1 of 66 patients assigned to placebo (1.5%, mean follow-up 2.3 +/- 1.1 years; P = 0.005, comparing remission rate in captopril vs. placebo-treated patients).(ABSTRACT TRUNCATED AT 250 WORDS)"
5.	Ischemia 04/01/2009 - "In isolated perfused hearts, recovery of left ventricular function from 40min of global ischemia was improved significantly in Ang-(1-7)- or captopril-treated diabetic SHR and worsened in animals treated with A779, an Ang-(1-7) receptor (AT((1-7))) antagonist. " 06/01/1992 - "Results suggest that captopril produced a significant improvement in the regional function parameters affected by ischemia both in total and partial obstructions." 07/01/1991 - "On the third day after ischemia, captopril significantly improved neurologic outcome (median deficit score = 4) compared with controls (median deficit score = 18) (p less than 0.05). " 05/01/2011 - "Recovery from global ischemia was also improved in isolated SHR-l hearts acutely perfused with captopril during both the perfusion and reperfusion periods. " 02/01/1993 - "The protective effects of captopril were evaluated in vitro on isolated perfused rat hearts after a global ischemia of 20 min. The hearts were randomly allocated in 2 groups. "

Related Drugs and Biologics

1.	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)
2.	Enalapril
3.	Renin
4.	Losartan (Cozaar)
5.	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)
6.	Hydrochlorothiazide (Esidrix)
7.	Angiotensin II
8.	Nifedipine (Adalat)
9.	Creatinine
10.	Lisinopril (Prinivil)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Nephrectomy
3.	Angioplasty (Angioplasty, Transluminal)
4.	Drug Therapy (Chemotherapy)
5.	Oral Administration