Xanthorrhizol has a potential to attenuate the high dose cisplatin-induced nephrotoxicity in mice.

Abstract

Cisplatin is a widely used anticancer drug, but it can produce undesirable side effects such as nephrotoxicity. The present study investigated the effect of xanthorrhizol isolated from Curcuma xanthorrhiza Roxb. (Zingiberaceae) on cisplatin-induced nephrotoxicity in mice. A single dose of cisplatin (45 mg/kg, i.p.) significantly elevated the levels of blood urea nitrogen, serum creatinine, and the kidney to body weight ratio, but the pretreatment of xanthorrhizol (200 mg/kg/day, per os) for 4 days significantly attenuated the cisplatin-induced nephrotoxicity. The preventive effect of xanthorrhizol was more efficacious than that of curcumin with the same amount (200 mg/kg). However, this effect seemed not to be related with the ability of xanthorrhizol to regulate the DNA-binding activities of transcription factors such as nuclear factor-kappaB (NF-kappaB) and activator protein 1 (AP-1). This is first time the preventive effect of xanthorrhizol on cisplatin-induced nephrotoxicity has been demonstrated, and these data suggest that the administration of xanthorrhizol is a promising approach in the treatment of nephrotoxicity caused by cisplatin.

• Authors: Seong Hwan Kim, Kyoung Ok Hong, Jae Kwan Hwang, Kwang-Kyun Park
• Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association (Food Chem Toxicol) Vol. 43 Issue 1 Pg. 117-22 (Jan 2005) ISSN: 0278-6915 [Print] England
• PMID: 15582203 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Phenols
• Transcription Factors
• xanthorrhizol
• Malondialdehyde
• Creatinine
• Curcumin
• Cisplatin

Topics

• Animals
• Antineoplastic Agents (adverse effects, therapeutic use)
• Blood Urea Nitrogen
• Cisplatin (adverse effects, therapeutic use)
• Creatinine (blood)
• Curcumin (pharmacology)
• Kidney (drug effects, metabolism)
• Male
• Malondialdehyde (metabolism)
• Mice
• Mice, Inbred ICR
• Organ Size (drug effects)
• Phenols (pharmacology)
• Random Allocation
• Transcription Factors (metabolism)
• Transcription, Genetic