Abstract | UNLABELLED: OBJECTIVE: METHODS: This was a double-blind, randomized controlled trial at an immediate care section of a suburban university-based ED with an annual census of 75,000. Adults with acute musculoskeletal pain without contraindications to the study medications were included. After recording their initial pain scores, patients were randomized to either oral valdecoxib 40 mg or oxycodone 10 mg with acetaminophen 650 mg. Pain scores were recorded at 30 and 60 minutes, and patients who requested additional pain relief were given an oral analgesic at the physician's discretion. Twenty-four-hour telephone follow-up was performed. The pain severity was recorded at 0, 30, and 60 minutes using a validated 100-mm visual analog scale marked "most" at the high end. The need for rescue medications and the occurrence of adverse events were determined. Study outcomes were compared with Student's t-test, repeated-measures analysis of variance (ANOVA), and chi(2) tests as appropriate. RESULTS: Fifty-one patients were randomized to valdecoxib (26) or oxycodone (25). Mean (+/- SD) age was 36 (+/- 14.7) years; 49% were women. Pain locations included extremities (49%), neck (29%), and back (22%). Baseline patient characteristics and pain severities were similar. There was no between-group difference in pain scores at 30 and 60 minutes. The changes in pain scores over time were also similar in the two study groups (repeated-measures ANOVA, p = 0.32). Patients treated with valdecoxib were less likely to experience sedation/ dizziness (15% vs. 44%, p = 0.03) and to require rescue medications within the next 24 hours (44% vs. 74%, p = 0.04). CONCLUSIONS:
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Authors | Stephanie J Lovell, Taku Taira, Erica Rodriguez, Andrew Wackett, Janet Gulla, Adam J Singer |
Journal | Academic emergency medicine : official journal of the Society for Academic Emergency Medicine
(Acad Emerg Med)
Vol. 11
Issue 12
Pg. 1278-82
(Dec 2004)
ISSN: 1069-6563 [Print] United States |
PMID | 15576517
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Analgesics
- Anti-Inflammatory Agents, Non-Steroidal
- Drug Combinations
- Isoxazoles
- Sulfonamides
- valdecoxib
- Acetaminophen
- Oxycodone
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Topics |
- Acetaminophen
(administration & dosage)
- Acute Disease
- Adult
- Analgesics
(administration & dosage)
- Anti-Inflammatory Agents, Non-Steroidal
(administration & dosage)
- Double-Blind Method
- Drug Combinations
- Emergency Medicine
(methods)
- Female
- Humans
- Isoxazoles
(administration & dosage)
- Male
- Musculoskeletal Diseases
(complications, drug therapy)
- Oxycodone
(administration & dosage)
- Pain
(diagnosis, drug therapy, etiology)
- Pain Measurement
- Prospective Studies
- Sulfonamides
(administration & dosage)
- Treatment Outcome
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