Abstract | BACKGROUND AND PURPOSE: METHODS: A total of 508 hypertensive, hypercholesterolemic patients with asymptomatic carotid atherosclerosis were randomized to: (A) hydrochlorothiazide; (B) fosinopril; (C) hydrochlorothiazide plus pravastatin; and (D) fosinopril plus pravastatin, and followed up blindly for 2.6 years. B-Mode carotid scans were performed yearly by certified sonographers in 13 hospitals and read centrally. Corrections for drift were calculated from readings repeated at study end. Primary outcome was change in mean maximum intima-media thickness of far and near walls of common carotids and bifurcations bilaterally (CBM(max)). RESULTS: CBM(max) significantly progressed (0.010+/-0.004 mm per year; P=0.01) in group A ( hydrochlorothiazide alone) but not in groups B, C, and D. CBM(max) changes in groups B, C, and D were significantly different from changes in group A. Changes in group A were concentrated at the bifurcations. "Clinic" and "ambulatory" blood pressure reductions were not significantly different between groups, but total and low-density lipoprotein cholesterol decreased by approximately 1 mmol/L in groups C and D. CONCLUSIONS:
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Authors | Alberto Zanchetti, Gaetano Crepaldi, M Gene Bond, Giuseppe Gallus, Fabrizio Veglia, Giuseppe Mancia, Alessandro Ventura, Giovannella Baggio, Lorena Sampieri, Paolo Rubba, Giovanni Sperti, Alberto Magni, PHYLLIS Investigators |
Journal | Stroke
(Stroke)
Vol. 35
Issue 12
Pg. 2807-12
(Dec 2004)
ISSN: 1524-4628 [Electronic] United States |
PMID | 15514192
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Angiotensin-Converting Enzyme Inhibitors
- Anticholesteremic Agents
- Antihypertensive Agents
- Diuretics
- Sodium Chloride Symporter Inhibitors
- Hydrochlorothiazide
- Pravastatin
- Fosinopril
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Topics |
- Aged
- Angiotensin-Converting Enzyme Inhibitors
(therapeutic use)
- Anticholesteremic Agents
(therapeutic use)
- Antihypertensive Agents
(therapeutic use)
- Carotid Stenosis
(complications, drug therapy, physiopathology)
- Disease Progression
- Diuretics
- Drug Therapy, Combination
- Female
- Fosinopril
(therapeutic use)
- Humans
- Hydrochlorothiazide
(therapeutic use)
- Hypercholesterolemia
(complications, drug therapy)
- Hypertension
(complications, drug therapy)
- Male
- Middle Aged
- Pravastatin
(therapeutic use)
- Sodium Chloride Symporter Inhibitors
(therapeutic use)
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