Quality of life impact of three different doses of suramin in patients with metastatic hormone-refractory prostate carcinoma: results of Intergroup O159/Cancer and Leukemia Group B 9480.

Abstract

BACKGROUND:

Research has suggested that men with hormone-refractory prostate carcinoma have a lower quality of life (QOL) compared with men who have hormone-sensitive prostate carcinoma and that quality of life (QOL) steadily declines over the last year of life for men with prostate carcinoma. The primary purpose of the current study was to evaluate whether there was evidence of palliative effects associated with suramin at any of the three doses administered in the original clinical trial.

METHODS:

Patients with histologically confirmed advanced hormone-refractory adenocarcinoma of the prostate were randomized to receive suramin at a low dose (n = 129; median age, 69 years), an intermediate dose (n = 129; median age, 71 years), or a high dose (n = 127; median age, 70 years) as part of the Intergroup 0159/Cancer and Leukemia Group B 9480 trial. Patients completed a battery of assessment tools, including the Functional Assessment of Cancer Therapy (FACT)-Prostate, the Center for Epidemiological Studies-Depression Scale (CES-D), the Brief Pain Inventory, and an opioid medication log, at baseline, on Day 1 of the sixth week of active therapy, during the second week after treatment termination, and 3 months after administration of the final suramin dose.

RESULTS:

Patients who received low-dose suramin reported improvement in QOL (FACT-General: P < 0.01; FACT-Treatment Outcome Index: P < 0.01) and decreased levels of depression (CES-D: P < 0.0006) during treatment compared with patients in the intermediate- and high-dose arms. After treatment, all groups experienced equal decreases in FACT and CES-D scores.

CONCLUSIONS:

The pattern of results suggests that the lowest dose of suramin administered had a palliative effect in terms of improvement in QOL and decreased levels of depression and that this effect was lost once suramin was discontinued.

• Authors: Tim A Ahles, James E Herndon 2nd, Eric J Small, Nicholas J Vogelzang, Alice B Kornblith, Mark J Ratain, Walter Stadler, David Palchak, M Ernest Marshall, George Wilding, Daniel Petrylak, Jimmie C Holland, Cancer and Leukemia Group B
• Journal: Cancer (Cancer) Vol. 101 Issue 10 Pg. 2202-8 (Nov 15 2004) ISSN: 0008-543X [Print] United States
• PMID: 15484217 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
• Copyright: (c) 2004 American Cancer Society

Chemical References

• Antineoplastic Agents
• Antineoplastic Agents, Hormonal
• Suramin

Topics

• Adenocarcinoma (drug therapy)
• Adult
• Aged
• Aged, 80 and over
• Antineoplastic Agents (adverse effects, therapeutic use)
• Antineoplastic Agents, Hormonal (therapeutic use)
• Dose-Response Relationship, Drug
• Drug Resistance, Neoplasm
• Humans
• Male
• Middle Aged
• Prostatic Neoplasms (drug therapy)
• Quality of Life
• Suramin (adverse effects, therapeutic use)