Abstract | PURPOSE: DESIGN: A prospective case-controlled study. METHODS: Ninety-two eyes of 46 NIDDM patients with clinically significant macular edema, poor metabolic control of diabetes, and peripheral neuropathy and 100 eyes of 50 normal control subjects were studied. The patients' eyes were assigned to argon green focal/grid laser photocoagulation using an applanation contact lens and one of the coupling fluids; 2% methocel, Thilo-Tears Gel, 1.4% sodium hyaluronate, or 0.9% simple saline. The control subjects received time-matched three-mirror contact lens fundus examinations. All subjects underwent corneal sensitivity measurements, Schirmer test, tear film breakup time, and corneal fluorescein staining before as well as 3 and 8 days after the laser procedures and contact lens examinations. Patients with corneal problems persisting after 8 days were followed longer. RESULTS: CONCLUSION: The use of viscous coupling solutions during applanation contact lens-aided laser procedures may be detrimental for the corneal epithelium in poorly controlled NIDDM patients with peripheral neuropathy and coexisting aqueous deficiency.
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Authors | Murat Dogru, Berkant Kaderli, Oner Gelisken, Ali Yücel, Remzi Avci, Eiki Goto, Shigeto Shimmura, Jun Shimazaki, Kazuo Tsubota |
Journal | American journal of ophthalmology
(Am J Ophthalmol)
Vol. 138
Issue 3
Pg. 381-8
(Sep 2004)
ISSN: 0002-9394 [Print] United States |
PMID | 15364219
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Ophthalmic Solutions
- Hyaluronic Acid
- Methylcellulose
- Fluorescein
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Topics |
- Adult
- Aged
- Case-Control Studies
- Contact Lenses
- Corneal Diseases
(chemically induced, metabolism, physiopathology)
- Diabetes Mellitus, Type 2
(complications, surgery)
- Diabetic Retinopathy
(etiology, surgery)
- Epithelium, Corneal
(drug effects, metabolism, physiopathology)
- Female
- Fluorescein
(metabolism)
- Fluorophotometry
- Humans
- Hyaluronic Acid
(adverse effects)
- Laser Coagulation
- Macular Edema
(etiology, surgery)
- Male
- Methylcellulose
(adverse effects)
- Middle Aged
- Ophthalmic Solutions
(adverse effects)
- Prospective Studies
- Tears
(physiology)
- Wound Healing
(drug effects)
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