Abstract | CONTEXT: OBJECTIVES: METHODS: MAIN OUTCOME MEASURES: Quantitative assessment of dysbindin mRNA levels across various brain regions and comparative studies of dysbindin mRNA levels in brains of patients with schizophrenia compared with normal controls. RESULTS:
Dysbindin mRNA was detected in the frontal cortex, temporal cortex, hippocampus, caudate, putamen, nucleus accumbens, amygdala, thalamus, and midbrain of the adult brain. Patients with schizophrenia had statistically significantly reduced dysbindin mRNA levels in multiple layers of the dorsolateral prefrontal cortex, whereas synaptophysin, spinophilin, and cyclophilin mRNA levels were unchanged. Dysbindin mRNA levels were quantitatively reduced in the midbrain of patients with schizophrenia, but not statistically significantly. Cortical dysbindin mRNA levels varied statistically significantly according to dysbindin genotype. CONCLUSIONS:
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Authors | Cynthia Shannon Weickert, Richard E Straub, Benjamin W McClintock, Mitsuyuki Matsumoto, Ryota Hashimoto, Thomas M Hyde, Mary M Herman, Daniel R Weinberger, Joel E Kleinman |
Journal | Archives of general psychiatry
(Arch Gen Psychiatry)
Vol. 61
Issue 6
Pg. 544-55
(Jun 2004)
ISSN: 0003-990X [Print] United States |
PMID | 15184234
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- 3' Untranslated Regions
- 5' Untranslated Regions
- Carrier Proteins
- DTNBP1 protein, human
- Dysbindin
- Dystrophin-Associated Proteins
- Microfilament Proteins
- Nerve Tissue Proteins
- RNA, Messenger
- Synaptophysin
- neurabin
- Cyclophilins
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Topics |
- 3' Untranslated Regions
(metabolism)
- 5' Untranslated Regions
(metabolism)
- Adult
- Aged
- Autoradiography
- Blotting, Northern
- Brain
(metabolism)
- Carrier Proteins
(genetics, metabolism)
- Cyclophilins
(metabolism)
- Dysbindin
- Dystrophin-Associated Proteins
- Female
- Gene Expression
- Genetic Predisposition to Disease
- Genotype
- Humans
- In Situ Hybridization
- Introns
(genetics, immunology)
- Male
- Mesencephalon
(metabolism)
- Microfilament Proteins
(metabolism)
- Middle Aged
- Nerve Tissue Proteins
(metabolism)
- Prefrontal Cortex
(metabolism)
- Promoter Regions, Genetic
(genetics)
- RNA, Messenger
(metabolism)
- Schizophrenia
(genetics, metabolism)
- Synaptophysin
(metabolism)
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