Abstract | BACKGROUND: METHODS: Rats were fed either on a normal rodent diet (group N) or a high- cholesterol supplemented diet (group H; 4% cholesterol and 1% cholic acid) for 8 weeks. Half of the animals (n = 6) from each diet group were then given a tail vein injection of 60% diatrizoate (6 ml/kg; group NC and group HC) and the other half were administered saline. Total serum cholesterol, triglyceride, serum creatinine, creatinine clearance rate, fractional excretion of sodium and potassium, and cortical nitric oxide production were determined one day following contrast media administration. Renal blood flow was determined by color Doppler flow imaging and pulsed-mode Doppler. Renal histopathology was observed by light microscopy. RESULTS: Total serum cholesterol and resistance indices of renal blood vessels increased significantly, while creatinine clearance rate and production of nitric oxide in the renal cortex decreased markedly in group HC and group H when compared to group N and group NC. The creatinine clearance rate decreased significantly in group HC compared to group H. Serum creatinine levels and fractional excretion of sodium and potassium in group HC were significantly higher than those in the other three groups. Severe tubular degeneration and necrosis, protein cast accumulation, and medullary congestion were found in group HC. CONCLUSION:
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Authors | Ding-Wei Yang, Ru-Han Jia, Ding-Ping Yang, Guo-Hua Ding, Cong-Xin Huang |
Journal | Chinese medical journal
(Chin Med J (Engl))
Vol. 117
Issue 4
Pg. 542-6
(Apr 2004)
ISSN: 0366-6999 [Print] China |
PMID | 15109446
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cholesterol, Dietary
- Contrast Media
- Lipids
- Nitric Oxide
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Topics |
- Animals
- Cholesterol, Dietary
(toxicity)
- Contrast Media
(toxicity)
- Kidney Diseases
(chemically induced)
- Lipids
(blood)
- Male
- Nitric Oxide
(biosynthesis)
- Rats
- Rats, Wistar
- Renal Circulation
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