Anti-inflammatory action of AGF44, a ganglioside ester derivative.

Abstract

Gangliosides (GA) have been shown to promote axonal sprouting and growth of injured peripheral nerves, and enhance functional biochemical and morphologic recovery after CNS damage. Moreover, it has recently been shown that the natural ganglioside mixture (GM1 + GD1a + GD1b + GT1b) from bovine brain is endowed with powerful anti-inflammatory activity in rodents. Here we report that the novel semisynthetic ganglioside derivative AGF44, the isopropyl ester of monosialoganglioside GM1, displays a potent anti-inflammatory activity when orally or topically administered in various models of acute inflammation. AGF44 was effective (0.5-5 mg/kg p.o. or 0.5% gel topical application) in reducing rat paw oedema induced by either carrageenin, histamine, bradykinin, serotonin, nystatin or kaolin. Moreover, crossed confrontation with the effects elicited by other anti-inflammatory agents revealed that AGE44 seems to act through a different pathway than NSAIDs, steroids or antihistaminic/antiserotoninic agents.

• Authors: M Amico-Roxas, A Caruso, V M Cutuli, U Scapagnini, A Morandi
• Journal: Drugs under experimental and clinical research (Drugs Exp Clin Res) Vol. 18 Issue 6 Pg. 251-9 ( 1992) ISSN: 0378-6501 [Print] Switzerland
• PMID: 1478165 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• G(M1) Ganglioside
• mipragoside

Topics

• Administration, Oral
• Administration, Topical
• Animals
• Anti-Inflammatory Agents, Non-Steroidal (administration & dosage, pharmacology)
• Drug Evaluation, Preclinical
• G(M1) Ganglioside (administration & dosage, analogs & derivatives, pharmacology)
• Inflammation (chemically induced, drug therapy)
• Male
• Mice
• Peritonitis (chemically induced, prevention & control)
• Rats
• Rats, Sprague-Dawley