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mipragoside

structure given in first source

Also Known As:

AGF44; ganglioside AGF44; monosialoganglioside GM1 isopropyl ester

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Related Diseases

1.	Allergic Conjunctivitis (Giant Papillary Conjunctivitis) 01/01/1996 - "Efficacy of mipragoside ophthalmic gel in vernal keratoconjunctivitis." 01/01/1996 - "We conclude that Mipragoside topical treatment improves symptoms of patients with vernal keratoconjunctivitis and we postulate a possible anti-inflammatory activity of this compound." 01/01/1996 - "To evaluate the efficacy of Mipragoside, a ganglioside derivative, in vernal keratoconjunctivitis we performed a controlled randomised clinical trial involving 24 patients (mean age 10 +/- 3.4 years, range 5-20 years). "
2.	Inflammation (Inflammations) 01/01/1993 - "Further, Mipragoside successfully reduced the primary signs of ocular inflammation produced by horse serum administration. " 01/01/1993 - "Effects of Mipragoside on ocular allergic inflammation in the rabbit." 01/01/1992 - "Here we report that the novel semisynthetic ganglioside derivative AGF44, the isopropyl ester of monosialoganglioside GM1, displays a potent anti-inflammatory activity when orally or topically administered in various models of acute inflammation. " 01/01/1993 - "We evaluated the pharmacodynamic and pharmacokinetic profile of Mipragoside, a monosialoganglioside isopropyl-ester (as 0.5% w/w ophthalmic gel), on allergic inflammation of the eye induced by reverse passive Arthus reaction, on a non-immune mast cell degranulation elicited by compound 48/80 and on ocular inflammation produced by horse serum. "
3.	Pruritus (Itching) 01/01/1996 - "Results show that Mipragoside significantly reduces all symptoms, being most effective on itching (p = 0.01; p = 0.0001) and hyperaemia (p = 0.01; p = 0.0006) after 1 and 2 weeks respectively when compared with placebo. "
4.	Arthus Reaction 01/01/1993 - "Mipragoside treatment significantly reduced (p < 0.05 vs placebo) the conjunctival vasopermeability induced by reverse passive Arthus reaction as well as successfully reduced the eosinophil levels in the conjunctival epithelium (p < 0.01 vs placebo) elicited by compound 48/80. " 01/01/1993 - "We evaluated the pharmacodynamic and pharmacokinetic profile of Mipragoside, a monosialoganglioside isopropyl-ester (as 0.5% w/w ophthalmic gel), on allergic inflammation of the eye induced by reverse passive Arthus reaction, on a non-immune mast cell degranulation elicited by compound 48/80 and on ocular inflammation produced by horse serum. "

Related Drugs and Biologics

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