Abstract | BACKGROUND: OBJECTIVE: DESIGN: A standard immunohistochemical technique was used on paraffin sections of 12 sporadic juvenile nasopharyngeal angiofibromas and 15 nasal polyps with microwave or steam antigen retrieval. Immunoreactivity was analyzed semiquantitatively in stromal cells and endothelial cells of each case. RESULTS: The expressions of beta-catenin (nuclear), c-Kit (cytoplasmic), and NGF (cytoplasmic) were higher and more frequent in stromal cells of juvenile nasopharyngeal angiofibromas than those of nasal polyps. Both juvenile nasopharyngeal angiofibromas and nasal polyps showed similarly frequent and strong immunoreactivity for p130Cas and TGF-beta3 and weak immunoreactivity for bone morphogenic protein 4 in both stromal cells and endothelial cells. No IGF-1R immunoreactivity was detected in any case of either group. CONCLUSIONS: Our results support the role of beta-catenin in juvenile nasopharyngeal angiofibromas and suggest a potential involvement of c-Kit and NGF signaling pathways in the juvenile nasopharyngeal angiofibromas. Although the biologic significance of c-Kit in juvenile nasopharyngeal angiofibromas has yet to be defined, the finding of frequent and high c-Kit expression might have therapeutic importance for patients with juvenile nasopharyngeal angiofibromas.
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Authors | Paul J Zhang, Randal Weber, Ho-Hi Liang, Teresa L Pasha, Virginia A LiVolsi |
Journal | Archives of pathology & laboratory medicine
(Arch Pathol Lab Med)
Vol. 127
Issue 11
Pg. 1480-4
(Nov 2003)
ISSN: 1543-2165 [Electronic] United States |
PMID | 14567719
(Publication Type: Journal Article)
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Chemical References |
- Antigens, Surface
- BCAR1 protein, human
- Bone Morphogenetic Proteins
- Crk-Associated Substrate Protein
- Growth Substances
- MAS1 protein, human
- Phosphoproteins
- Proteins
- Proto-Oncogene Mas
- Receptors, Progesterone
- Retinoblastoma Protein
- Retinoblastoma-Like Protein p130
- Transforming Growth Factor beta
- Transforming Growth Factor beta3
- Nerve Growth Factor
- Proto-Oncogene Proteins c-kit
- Receptor, IGF Type 1
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Topics |
- Adolescent
- Adult
- Angiofibroma
(chemistry, pathology)
- Antigens, Surface
(biosynthesis, immunology)
- Bone Morphogenetic Proteins
(biosynthesis, immunology)
- Child
- Crk-Associated Substrate Protein
- Growth Substances
(biosynthesis, immunology)
- Humans
- Immunohistochemistry
(methods)
- Male
- Nasal Polyps
(chemistry, pathology)
- Nasopharyngeal Neoplasms
(chemistry, pathology)
- Nerve Growth Factor
(biosynthesis, immunology)
- Paraffin Embedding
- Phosphoproteins
(biosynthesis, immunology)
- Proteins
- Proto-Oncogene Mas
- Proto-Oncogene Proteins c-kit
(biosynthesis, immunology)
- Receptor, IGF Type 1
(biosynthesis, immunology)
- Receptors, Progesterone
(biosynthesis, immunology)
- Retinoblastoma Protein
(biosynthesis, immunology)
- Retinoblastoma-Like Protein p130
- Transforming Growth Factor beta
(biosynthesis, immunology)
- Transforming Growth Factor beta3
|