Abstract | BACKGROUND: METHODS: A prospective, randomized, double-blind study of 38 patients undergoing laparoscopic surgery during general anesthesia was performed. Acetazolamide (5 mg/kg) or a saline placebo was administered intravenously during surgery. Pain was rated on a visual analog scale (0-10) at four times: when first awake, at discharge from the recovery room, when discharged from the hospital, and on the day after surgery. The site and quality of pain were recorded, as were medications and side effects. RESULTS: CONCLUSIONS:
Acetazolamide reduces referred but not incisional pain after laparoscopic surgical procedures. The duration of pain reduction is limited to the immediate postsurgical period.
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Authors | Harvey J Woehlck, Mary Otterson, Hyun Yun, Lois A Connolly, Daniel Eastwood, Krista Colpaert |
Journal | Anesthesiology
(Anesthesiology)
Vol. 99
Issue 4
Pg. 924-8
(Oct 2003)
ISSN: 0003-3022 [Print] United States |
PMID | 14508327
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Carbon Dioxide
- Acetazolamide
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Topics |
- Acetazolamide
(therapeutic use)
- Adult
- Carbon Dioxide
- Double-Blind Method
- Humans
- Insufflation
(methods)
- Laparoscopy
(adverse effects, methods)
- Logistic Models
- Odds Ratio
- Pain, Postoperative
(drug therapy, etiology)
- Postoperative Care
(methods)
- Prospective Studies
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