GALLSTONES PRODUCED EXPERIMENTALLY BY LITHOCHOLIC ACID IN RATS.

Abstract

Administration of lithocholic acid (1 percent in the diet) consistently produces choledocholithiasis in 8 weeks in rats on an 8-percent protein diet. The gallstones consist predominantly of the calcium salts of free and glycine-conjugated lithocholic and 3alpha,6beta-dihydroxy-5beta-cholanic acids. Conjugation of bile acid with taurine can be enhanced and stone formation can be inhibited by an increase in the dietary protein or by a diet supplemented with taurine.

• Authors: R H PALMER
• Journal: Science (New York, N.Y.) (Science) Vol. 148 Issue 3675 Pg. 1339-40 (Jun 04 1965) ISSN: 0036-8075 [Print] United States
• PMID: 14281716 (Publication Type: Journal Article)

Chemical References

• Bile Acids and Salts
• Dietary Proteins
• Salts
• Taurine
• Lithocholic Acid
• Glycine

Topics

• Bile Acids and Salts
• Diet
• Dietary Proteins
• Gallstones
• Glycine
• Lithocholic Acid
• Liver
• Pharmacology
• Rats
• Research
• Salts
• Taurine
• Toxicology