Abstract | BACKGROUND: Progress in the treatment of brain neoplasms requires accurate identification of tumor type and grade, before a proper treatment plan can be implemented. The aim of our study was to investigate the use of proton magnetic resonance spectroscopy in the differential diagnosis of neoplastic brain tumors and tumor-like processes. MATERIAL/METHODS: 29 patients with ambiguous CT images of brain mass lesions were examined by MRI. 1H MRS was applied in this group as the primary option to improve differential diagnosis. In each case a routine MRI was taken in three orthogonal planes before and after i.v. administration of Gd-DTPA. 1H MRS was performed at 1.5 T using the PRESS (TE 136 ms) and STEAM (TE 20 ms) single voxel spectroscopy techniques. MRS was performed after i.v. administration of Gd-DTPA. The lesion types according to spectral patterns were compared to postoperative pathology or biopsy results. RESULTS: CONCLUSIONS: 1HMRS proved to be a useful tool in establishing tumor type and differentiating between neoplastic and large inflammatory tumor-like lesions.
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Authors | Witold Gajewicz, Wielislaw Papierz, Wiesław Szymczak, Bozena Goraj |
Journal | Medical science monitor : international medical journal of experimental and clinical research
(Med Sci Monit)
Vol. 9
Issue 9
Pg. MT97-105
(Sep 2003)
ISSN: 1234-1010 [Print] United States |
PMID | 12960934
(Publication Type: Evaluation Study, Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Astrocytoma
(diagnosis, metabolism, pathology)
- Brain
(pathology)
- Brain Neoplasms
(diagnosis, metabolism, pathology)
- Diagnosis, Differential
- Female
- Glioblastoma
(diagnosis, metabolism, pathology)
- Humans
- Inflammation
(diagnosis, etiology, metabolism, pathology)
- Magnetic Resonance Imaging
(methods)
- Male
- Meningioma
(diagnosis, metabolism, pathology)
- Middle Aged
- Neoplasm Metastasis
(diagnosis, pathology)
- Oligodendroglioma
(diagnosis, metabolism, pathology)
- Protons
- Sensitivity and Specificity
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