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Meningioma (Meningiomas)

A relatively common neoplasm of the CENTRAL NERVOUS SYSTEM that arises from arachnoidal cells. The majority are well differentiated vascular tumors which grow slowly and have a low potential to be invasive, although malignant subtypes occur. Meningiomas have a predilection to arise from the parasagittal region, cerebral convexity, sphenoidal ridge, olfactory groove, and SPINAL CANAL. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2056-7)

Also Known As:

Meningiomas; Sphenoid Wing Meningioma; Angioblastic Meningioma; Angiomatous Meningioma; Cerebral Convexity Meningioma; Clear Cell Meningioma; Fibrous Meningioma; Hemangioblastic Meningioma; Hemangiopericytic Meningioma; Intracranial Meningioma; Intraorbital Meningioma; Intraventricular Meningioma; Meningotheliomatous Meningioma; Microcystic Meningioma; Olfactory Groove Meningioma; Papillary Meningioma; Parasagittal Meningioma; Posterior Fossa Meningioma; Psammomatous Meningioma; Secretory Meningioma; Spinal Meningioma; Transitional Meningioma; Xanthomatous Meningioma; Angioblastic Meningiomas; Angiomatous Meningiomas; Benign Meningiomas; Cerebral Convexity Meningiomas; Clear Cell Meningiomas; Convexity Meningioma, Cerebral; Convexity Meningiomas, Cerebral; Fibrous Meningiomas; Groove Meningiomas, Olfactory; Hemangioblastic Meningiomas; Hemangiopericytic Meningiomas; Intracranial Meningiomas; Intraorbital Meningiomas; Intraventricular Meningiomas; Malignant Meningiomas; Meningioma, Angioblastic; Meningioma, Angiomatous; Meningioma, Benign; Meningioma, Cerebral Convexity; Meningioma, Clear Cell; Meningioma, Fibrous; Meningioma, Hemangioblastic; Meningioma, Hemangiopericytic; Meningioma, Intracranial; Meningioma, Intraorbital; Meningioma, Intraventricular; Meningioma, Malignant; Meningioma, Meningotheliomatous; Meningioma, Microcystic; Meningioma, Multiple; Meningioma, Olfactory Groove; Meningioma, Papillary; Meningioma, Parasagittal; Meningioma, Posterior Fossa; Meningioma, Psammomatous; Meningioma, Secretory; Meningioma, Sphenoid Wing; Meningioma, Spinal; Meningioma, Transitional; Meningioma, Xanthomatous; Meningiomas, Angioblastic; Meningiomas, Angiomatous; Meningiomas, Benign; Meningiomas, Cerebral Convexity; Meningiomas, Clear Cell; Meningiomas, Fibrous; Meningiomas, Hemangioblastic; Meningiomas, Hemangiopericytic; Meningiomas, Intracranial; Meningiomas, Intraorbital; Meningiomas, Intraventricular; Meningiomas, Malignant; Meningiomas, Meningotheliomatous; Meningiomas, Microcystic; Meningiomas, Olfactory Groove; Meningiomas, Papillary; Meningiomas, Parasagittal; Meningiomas, Posterior Fossa; Meningiomas, Psammomatous; Meningiomas, Secretory; Meningiomas, Sphenoid Wing; Meningiomas, Spinal; Meningiomas, Transitional; Meningiomas, Xanthomatous; Meningiomatoses; Meningotheliomatous Meningiomas; Microcystic Meningiomas; Multiple Meningioma; Multiple Meningiomas; Olfactory Groove Meningiomas; Papillary Meningiomas; Parasagittal Meningiomas; Posterior Fossa Meningiomas; Psammomatous Meningiomas; Secretory Meningiomas; Sphenoid Wing Meningiomas; Spinal Meningiomas

Networked: 3961 relevant articles (134 outcomes, 589 trials/studies)

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Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Meningioma (Meningiomas)
3.	Neurilemmoma (Schwannoma)
4.	Glioma (Gliomas)
5.	Glioblastoma (Glioblastoma Multiforme)

Experts

1.	McDermott, Michael W: 28 articles (05/2015 - 01/2004)
2.	Debus, Jürgen: 23 articles (04/2015 - 02/2003)
3.	Mawrin, Christian: 19 articles (12/2015 - 01/2004)
4.	Gutmann, David H: 17 articles (01/2014 - 05/2002)
5.	Chamberlain, Marc C: 16 articles (09/2015 - 04/2004)
6.	Parsa, Andrew T: 16 articles (02/2015 - 10/2006)
7.	Perry, Arie: 15 articles (09/2015 - 05/2002)
8.	Johnson, Mahlon D: 15 articles (04/2015 - 01/2002)
9.	Black, Peter M: 15 articles (10/2011 - 01/2003)
10.	Combs, Stephanie E: 14 articles (04/2015 - 01/2010)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Meningioma:

1.	Protons (Proton)IBA 06/01/2000 - "However, significantly improved local control was observed for proton versus photon RT (80% versus 17% at 5 years, p = 0.003) and target doses > or = 60 Gy for both, atypical (p = 0.025) and malignant meningioma (p = 0.0006). " 01/01/2001 - "Proton irradiation is effective and safe in controlling large and complex-shaped skull base meningiomas." 06/01/2004 - "To assess the safety and efficacy of spot scanning proton beam radiation therapy (PRT) in the treatment of intracranial meningiomas. " 01/01/2015 - "This study compares the dose distributions of complex meningioma plans produced by three proton TPSs: Eclipse, Pinnacle3, and XiO. " 12/01/2012 - "Purpose of this study was to determine the toxicity and treatment outcome after dose escalation with proton radiation therapy for patients with World Health Organization (WHO) grade II and grade III meningiomas. "
2.	bevacizumab FDA Link 12/01/2015 - "In addition, we provide a review of the literature regarding the efficacy of bevacizumab in the treatment of recurrent meningiomas. " 01/01/2015 - "The efficacy of bevacizumab has not been determined for treatment-refractory meningiomas. " 04/01/2014 - "Recently two retrospective cohort studies report efficacy of bevacizumab in patients with recurrent atypical and anaplastic meningioma. " 08/01/2012 - "Prospective studies are required to define the safety and efficacy of bevacizumab in atypical and anaplastic meningiomas." 01/01/2013 - "These results are comparable to previous studies of bevacizumab in sporadic meningiomas."
3.	(DOTA(0)-Phe(1)-Tyr(3))octreotide (SMT 487)IBA 09/01/2012 - "Ga-DOTATOC PET/CT demonstrated an improved sensitivity in meningioma detection when compared to CE-MRI. " 03/01/2015 - "A very unusual and aggressive form of a primary pulmonary meningioma seen with a ⁶⁸Ga-DOTATOC PET/CT image." 02/01/2015 - "(68)Ga-DOTATOC-PET/MRI provided flawless image quality and presented an ideal combination of high sensitivity/specificity (PET) and the best possible morphological visualization of meningiomas (MRI). " 02/01/2015 - "Fifteen patients received (68)Ga-DOTATOC-PET/CT (0.5 h post injection [p.i.]) followed by PET/MRI 2 hours p.i. Both investigations were analyzed separately and then compared with respect to image quality, detection of intracranial meningiomas, and radiotracer uptake values (RUVs). " 02/01/2015 - "Comparison of ⁶⁸Ga-DOTATOC-PET/CT and PET/MRI hybrid systems in patients with cranial meningioma: Initial results."
4.	DNA (Deoxyribonucleic Acid)IBA 01/01/1989 - "The determination of nuclear DNA contents did not add further information useful in the management of these meningioma patients. " 02/01/2015 - "We analysed genome wide expression profiles of 119 meningioma samples from two previous published DNA microarray studies. " 10/01/2005 - "In this study, we used DNA microarray assay, which detects numerous genetic abnormalities simultaneously and analyses a global assessment of molecular events in meningioma cells. " 07/01/2003 - "Recurrent and atypical meningiomas--a multiparametric study using Ki67 labelling index, AgNOR and DNA Feulgen staining." 08/01/1999 - "In the present study, we determined the clonality, methylation status of deoxyribonucleic acid, and relationship of genetic alterations in eight meningiomas from one female patient. "
5.	Somatostatin Receptors (Somatostatin Receptor)IBA 04/01/2005 - "This study investigates a possible relationship between the effects of gamma knife (GK) on meningioma somatostatin receptors (SRs) and the high rate of early neurological improvement without tumour reduction at short-term imaging follow-up. " 04/01/1996 - "The aim of this study was to evaluate somatostatin receptor scintigraphy (SRS) in patients with meningioma proven or suspected on magnetic resonance imaging (MRI). " 07/01/1993 - "Somatostatin receptors in meningiomas: a scintigraphic study using 111In-DTPA-D-Phe-1-octreotide." 07/01/2015 - "In our case, we have shown that meningioma with extracranial locations may present high uptake of somatostatin receptor analogues. " 02/01/2015 - "Meningiomas express members of the somatostatin receptor family. "
6.	Progesterone FDA LinkGeneric 10/01/1994 - "It was obtained by synthesis a radioprogestin-iodine-131 and proved in two patients with hormono-dependent meningioma to progesterone with very good results in the scan of cerebral tumours localization; and in one patient in the treatment of this kind of tumour. " 10/01/2004 - "Previous studies indicate that progesterone and its receptors can play a role in the recurrence of meningiomas, but the correlation between the presence of these receptors and patients' outcome is unclear. " 06/01/1994 - "Clinical trials with anti-oestrogens have shown little effect while trials with progesterone agonists have shown no effect or possible stimulation of meningioma growth. " 03/01/1989 - "The results of this study suggest that the modulation of progesterone levels may be of therapeutic usefulness, particularly in patients with recurrent malignant meningiomas." 10/01/2014 - "In particular, progesterone, has a receptor (PR) that is highly expressed in the majority of grade I meningiomas. "
7.	Hydroxyurea (Hydrea)FDA LinkGeneric 09/01/2004 - "The purpose of this prospective phase II study was to evaluate the efficacy of hydroxyurea treatment for unresectable progressive meningioma. " 12/01/2012 - "This study showed that hydroxyurea is a modestly active agent against recurrent meningiomas and can induce long-term stabilization of disease in some patients. " 01/01/2012 - "Phase II study of Gleevec® plus hydroxyurea (HU) in adults with progressive or recurrent meningioma." 01/01/2007 - "Results of preliminary clinical studies suggest that hydroxyurea has modest activity against recurrent and inoperable meningiomas, and can induce long term stabilization in some patients. " 10/01/2004 - "In the current study, 21 patients with meningioma have been placed on hydroxyurea (20 mg/kg/day orally), with extended follow-up of the original cohort. "
8.	HormonesIBA 09/01/2006 - "These data add to the evidence that factors known to influence endogenous hormones (pregnancy and indirectly smoking) may have protective effects for meningiomas primarily in premenopausal women." 01/01/2016 - "Previous studies suggest that hormone therapy may play an important role in the development of meningioma. " 12/01/2011 - "The influence of genetics, the immune system, and radiation near the head on meningioma risk is suggested in the authors' findings; the role of hormones is intriguing but requires further study." 10/01/2006 - "This study aims to evaluate the hormone receptor status of meningiomas and assess its relation to age, sex, histological grade, recurrence, and proliferation activity. " 12/01/2005 - "Few studies have examined the risk factors associated with a diagnosis of meningioma with two categories of exposure, hormones (both endogenous and exogenous) and radiation, most strongly associated with meningioma risk. "
9.	Mifepristone (RU 486)FDA Link 07/01/1998 - "Unresectable meningioma treated with 200 or 400 mg/d of mifepristone produced objective improvement in about 25% of subjects. " 12/01/2015 - "This multicenter, prospective, randomized, placebo-controlled phase III trial conducted by SWOG was planned to define the role of mifepristone in the treatment of unresectable meningioma. " 12/01/2015 - "Double-Blind Phase III Randomized Trial of the Antiprogestin Agent Mifepristone in the Treatment of Unresectable Meningioma: SWOG S9005." 01/01/2015 - "Concerning clinical studies, the response rate to mifepristone in terms of radiological regression and symptomatic improvement/stability in patients with inoperable meningioma was low. " 11/01/2006 - "The purpose of this study was to test the effects of the addition of a CCA to HU or RU486 on meningioma growth. "
10.	Octreotide (Sandostatin)FDA LinkGeneric 05/01/2014 - "A prospective, two-stage phase II trial with octreotide in patients with recurrent high-grade meningioma was conducted. " 03/01/2013 - "Thirty patients with meningiomas diagnosed by MRI and considered as the study group were treated with Tc-HYNIC-octreotide SPECT/CT preoperatively and pathologically examined postoperatively. " 03/01/2013 - "Tc-HYNIC-octreotide SPECT/CT SRS is a sensitive technique for detecting meningiomas, and radio guidance using a hand-held γ-probe with Tc-HYNIC-octreotide during surgery can significantly reduce the recurrence of meningiomas." 10/01/2011 - "The usefulness of ¹¹¹In-octreotide scintigraphy should be considered in staging patients with recurrent meningioma who are considered for further treatment. " 05/01/2011 - "Between January 1996 and December 2010, 13 patients harboring a progressive residual meningioma (as indicated by MR imaging criteria) following operative therapy were treated with a monthly injection of the SST analog octreotide (Sandostatin LAR [long-acting repeatable] 30 mg, Novartis). "

Therapies and Procedures

1.	Radiotherapy 02/01/2014 - "However, radiotherapy and radiosurgery have proven effective for SC meningiomas. " 12/01/2014 - "This large study showed that fractionated stereotactic radiotherapy is an effective and safe treatment modality with high progression-free survival rates for intracranial meningioma. " 01/01/2013 - "The ongoing EORTC 22042-26042 trial evaluates the efficacy of high-dose radiotherapy (RT) in atypical/malignant meningioma. " 09/01/2014 - "Efficacy of postoperative radiotherapy for high grade meningiomas." 12/01/2013 - "For standard first-line treatment of high-grade meningiomas, surgical resection and radiotherapy are regarded as standard of care. "
2.	Particle Accelerators 02/01/2012 - "Linear accelerator fractionated RT using the multiple noncoplanar dynamic rotation conformal paradigm can be offered to patients with meningiomas that threaten the anterior visual pathways as an adjunct to surgery or as first-line treatment, with results comparable to those reported for other stereotactic RT techniques." 09/01/2011 - "We evaluated the efficacy of linear accelerator (LINAC) radiosurgery for atypical and anaplastic meningiomas after incomplete resection or treatment of recurrences. " 07/01/2013 - "The aim of this study was to evaluate the efficiency of linear accelerator (LINAC)-based SRS in the management of meningiomas and to report our experience using this sophisticated technique. " 01/01/2011 - "The purpose of this study is to evaluate the short-term radiological and functional outcomes of a single center using linear accelerator (Linac) stereotactic radiosurgery for the treatment of intracranial meningiomas. " 01/01/2011 - "The aim of the present study is to determine and compare initial treatment costs of microsurgery, linear accelerator (LINAC) radiosurgery, and gamma knife radiosurgery in meningioma patients. "
3.	Lasers (Laser) 01/01/1992 - "Concerning meningiomas, patients of both groups (with and without laser) were clinically improved during the post-operative period. " 05/01/2012 - "When addressed with the laser, all nine meningiomas presented a crater having an average depth of 1 mm. Three layers were clearly distinguished and measured: A (average depth: 0.8 mm at 6 W and 1.24 mm at 12 W); B (average depth: 0.32 mm at 6 W and 0.72 mm at 12 W); and C (average depth: 0.39 mm at 6 W and 0.44 mm at 12 W). " 01/01/2012 - "This paper describes our first experience of PDD combined with laser spectroanalysis in intracranial meningiomas. " 01/01/2012 - "[First experience of photodynamic diagnosis and laser spectroalanysis in surgery of intracranial meningiomas]." 04/01/2010 - "Imaging of meningioma progression by matrix-assisted laser desorption ionization time-of-flight mass spectrometry."
4.	Conformal Radiotherapy 12/01/1996 - "We report a case of visual improvement in a patient with an optic nerve sheath meningioma and progressive visual field loss, treated with conformal radiotherapy." 10/01/2012 - "Fractionated stereotactic conformal radiotherapy for optic nerve sheath meningiomas." 05/01/2011 - "To provide the long-term outcomes of patients treated with fractionated conformal radiotherapy (FCRT) for presumed optic nerve sheath meningiomas (ONSMs). " 01/01/2011 - "Fractionated stereotactic conformal radiotherapy for large benign skull base meningiomas." 11/01/2010 - "To evaluate long-term outcome of cavernous sinus meningioma (CSM) treated with fractionated conformal radiotherapy (FCR). "
5.	Craniotomy 12/01/2004 - "Tuberculum sellae meningioma was removed through a craniotomy, and his symptoms improved. " 12/01/2014 - "The aim of the present study was to examine whether putative alterations in peritumoral tissue biochemistry, monitored by microdialysis, correlate with clinical outcome in patients undergoing craniotomy for meningioma resection. " 01/01/2013 - "According to the nationwide inpatient sample (NIS) database, an estimated 72,257 adult meningioma patients underwent a craniotomy in US hospitals during the study period. " 11/01/2005 - "The aim of this study is specifically to analyze the results of pterional craniotomy for tuberculum sellae meningiomas. " 07/01/2000 - "The aim of this study was to investigate the possible benefits of image-guided craniotomies to treat meningiomas, in terms of hospital stays, surgical complications, and, consequently, cost-effectiveness, compared with the results of standard surgery (SS). "