The influences of extremely low frequency magnetic fields on drug-induced convulsion in mouse.

Abstract

This study investigated the effects of extremely low frequency magnetic fields (ELF-MFs) on the sensitivity of seizure response to bicuculline, picrotoxin and NMDA in mice. The mice were exposed to either a sham or 20 G ELF-MFs for 24 hours. Convulsants were then administered i.p. at various doses. The seizure induction time and duration were measured and lethal dose (LD50) and convulsant dose (CD50) of the clonic and tonic convulsion were calculated. The analysis of glutamate, glycine, taurine and GABA of mouse brain was accomplished by HPLC. The mice exposed to ELF-MFs showed moderately higher CD50, LD50 and onset time on the bicuculline-induced seizure. However, the ELF-MFs did not influence them in the NMDA and picrotoxin-induced seizures. After the exposure to MFs exposure, the glutamate level was increased and GABA was decreased significantly in NMDA and picrotoxin-induced seizure. The level of glutamate and GABA were not changed by MFs in bicuculline-induced seizure. These results suggest that ELF-MFs may alter the convulsion susceptibility through GABAergic mechanism with the involvement of the level of glutamate and GABA.

• Authors: Ji Hyun Sung, Ji Hoon Jeong, Jeong Soo Kim, Tai Sik Choi, Joon Hong Park, Hoe Yun Kang, Young Sil Kim, Dong Suk Kim, Uy Dong Sohn
• Journal: Archives of pharmacal research (Arch Pharm Res) Vol. 26 Issue 6 Pg. 487-92 (Jun 2003) ISSN: 0253-6269 [Print] Korea (South)
• PMID: 12877560 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Convulsants

Topics

• Animals
• Brain (drug effects, metabolism)
• Convulsants (toxicity)
• Dose-Response Relationship, Drug
• Electromagnetic Fields (adverse effects)
• Mice
• Mice, Inbred ICR
• Seizures (chemically induced, metabolism)