Topical therapy for actinic keratoses, I: 5-Fluorouracil and imiquimod.

Abstract

Actinic keratoses (AKs) are evolving, malignant cutaneous neoplasms. AKs can be treated with physical or destructive methods and with topical therapies. This article is the first in a 2-part series that will review current topical therapeutic options for AKs. Several topical treatment options offer some significant benefit for the alleviation of these lesions. Therapies include 5-fluorouracil, imiquimod, diclofenac, colchicine, and retinoids. The first part of this review will focus on topical 5-fluorouracil and imiquimod.

• Authors: William D Tutrone, Ritu Saini, Selin Caglar, Jeffrey M Weinberg, Jorge Crespo
• Journal: Cutis (Cutis) Vol. 71 Issue 5 Pg. 365-70 (May 2003) ISSN: 0011-4162 [Print] United States
• PMID: 12769403 (Publication Type: Journal Article, Review)

Chemical References

• Aminoquinolines
• Antimetabolites, Antineoplastic
• Antineoplastic Agents
• Imiquimod
• Fluorouracil

Topics

• Administration, Cutaneous
• Aminoquinolines (administration & dosage, therapeutic use)
• Antimetabolites, Antineoplastic (administration & dosage, therapeutic use)
• Antineoplastic Agents (administration & dosage, therapeutic use)
• Fluorouracil (administration & dosage, therapeutic use)
• Humans
• Imiquimod
• Keratosis (drug therapy, pathology)
• Precancerous Conditions (drug therapy, pathology)
• Randomized Controlled Trials as Topic
• Skin Neoplasms (drug therapy, pathology)