Colchicine

A major alkaloid from Colchicum autumnale L. and found also in other Colchicum species. Its primary therapeutic use is in the treatment of gout, but it has been used also in the therapy of familial Mediterranean fever (PERIODIC DISEASE).

Also Known As:

Networked: 3032 relevant articles (291 outcomes, 370 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Imazio, Massimo: 36 articles (11/2015 - 09/2005)
2.	Livneh, Avi: 26 articles (05/2015 - 04/2003)
3.	Adler, Yehuda: 23 articles (12/2014 - 12/2002)
4.	Brucato, Antonio: 22 articles (12/2014 - 04/2005)
5.	Trinchero, Rita: 20 articles (12/2014 - 09/2005)
6.	Spodick, David H: 19 articles (07/2015 - 04/2005)
7.	Lidar, Merav: 17 articles (05/2015 - 12/2003)
8.	Hamel, Ernest: 17 articles (04/2015 - 01/2005)
9.	Schlesinger, Naomi: 15 articles (01/2015 - 07/2007)
10.	Belli, Riccardo: 11 articles (12/2014 - 09/2005)

Related Diseases

1.	Amyloidosis 08/01/2008 - "Colchicine is highly effective in the treatment of FMF and in preventing the development of recurrent attacks and amyloidosis, and it is essential to make the correct diagnosis and institute daily therapy with colchicine (0.5-0.6 mg bid). " 07/23/2005 - "The curative efficacy of colchicine on flares is debatable, although several studies report positive results against progression of early amyloidosis." 06/01/2015 - "Optimal colchicine dose is effective in preventing and reversing renal amyloidosis. " 05/01/2012 - "When used in proper doses and with compliance, colchicine is very effective in preclinical and proteinuric stages of FMF-related amyloidosis. " 07/31/2004 - "The indication for colchicine is important to consider particularly since the response of amyloidosis to the treatment of the causal disease does not, in the majority of cases, lead to the remission of the amyloidosis, the prognosis of which is determined by the extent of renal involvement."
2.	Familial Mediterranean Fever (Periodic Disease) 01/01/1983 - "Of 85 patients with familial Mediterranean fever receiving continuous prophylactic colchicine therapy, 62 (73 percent) have had a significant reduction in the severity and frequency of their attacks. " 05/01/2014 - "Colchicine is the main treatment for familial Mediterranean fever (FMF). " 01/01/2014 - "To demonstrate and clinically, genetically and demographically characterize familial Mediterranean fever (FMF) patients, maintaining remission despite colchicine abstinence. " 05/01/2009 - "Currently, the only effective treatment of Familial Mediterranean Fever is the colchicine. " 07/01/2007 - "Colchicine is a mainstay of treatment in familial Mediterranean fever (FMF); however, 5%-10% of patients do not respond to colchicine. "
3.	Pericarditis 10/01/2009 - "Based on the proven efficacy of colchicine in preventing polyserositis in FMF, colchicine has been proposed for the treatment of recurrent pericarditis and is able to decrease the recurrence rate. " 01/01/2006 - "A multidrug protocol including non-steroidal anti-inflammatory drugs at high dosage, slow tapering of corticosteroid, colchicine, reassurance and close clinical monitoring is very effective in recurrent pericarditis; this improvement is more dramatic in colchicine treated patients, but also patients who do not tolerate it can achieve good control of the disease." 03/01/1994 - "We confirm the results of a previous trial which showed that colchicine may be beneficial in preventing the recurrence of pericarditis. " 01/01/2014 - "Colchicine has been suggested to be beneficial in preventing recurrent pericarditis. " 03/01/1993 - "This observation raises the question whether colchicine might be beneficial in recurrent benign pericarditis with or without corticodependence and have a prophylactic action against recurrences."
4.	Gout 12/01/2010 - "Low-dose and high-dose colchicine have comparable efficacy in the treatment of acute gout, but high dose carries significantly greater risk of adverse effects." 01/01/2006 - "Colchicine is regarded as beneficial in the treatment of acute gout, but has a high frequency of gastrointestinal adverse events. " 01/01/2014 - "Based upon only two published trials, there is low-quality evidence that low-dose colchicine is likely to be an effective treatment for acute gout. " 04/10/1987 - "Colchicine has the smallest benefit-to-toxicity ratio of drugs that are effective for acute gout. " 02/02/2011 - "Small doses of colchicine are useful in the treatment of gout. "
5.	Fibrosis (Cirrhosis) 12/01/2010 - "Topical application of colchicine is very effective in preventing epidural fibrosis." 06/01/1990 - "Finally, colchicine may prove to be effective in slowing the rate of fibrosis in cirrhosis, but this has yet to be conclusively proven." 04/01/2005 - "In 54 patients with repeat liver biopsies after 24 or more months of treatment, cirrhosis improved to septal fibrosis in 7 patients (3 colchicine, 4 placebo) and to portal fibrosis in 1 patient (colchicine). " 11/15/2000 - "In summary, colchicine has only weak antioxidant properties, but does afford some protection against oxidative stress; more importantly, long term treatment with this drug may be of value in producing regression of established cirrhosis." 05/01/1997 - "Colchicine is effective in decreasing hepatic fibrosis. "

Related Drugs and Biologics

1.	Adrenal Cortex Hormones (Corticosteroids)
2.	Methotrexate (Mexate)
3.	Steroids
4.	Ursodeoxycholic Acid (Urso)
5.	Interleukin 1 Receptor Antagonist Protein (Anakinra)
6.	Dapsone
7.	Cyclosporine (Ciclosporin)
8.	Amyloid (Amyloid Fibrils)
9.	canakinumab
10.	Prednisone (Sone)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Aftercare (After-Treatment)
3.	Transplants (Transplant)
4.	Pericardiectomy
5.	Stents