Abstract | BACKGROUND: METHODS: Twenty patients participated in this study. Ten biopsies from healthy keratinized mucosa and 10 biopsies from peri-implant soft tissues surrounding failing implants were obtained (one biopsy per patient). The biopsies were obtained from different patients. RESULTS: In 5 cases of healthy mucosa, the stromal cells were positive between 1 to 5. In 7 cases, the epithelial layers were positive, between 1 and 18 cells. The superficial epithelial layer was negative in all cases. In 9 cases, there was a positivity of the vascular component, between 2 and 16 vessels. In failing implants, the stromal cells were positive in 6 cases, between 1 and 4. In all cases, cells of the epithelial layers were positive, between 15 and 40. The vascular component was positive in all cases, between 12 and 30 vessels. The differences between TGF-beta1 expression in the epithelium around healthy and failing implants were statistically significant (P < 0.0001). The differences between TGF-beta1 expression in the blood vessels in the soft tissues around healthy and failing implants were also statistically significant (P < 0.0001). No statistically significant difference was observed between the 2 groups in the TGF-beta1 expression in the stromal cells (P = 0.88). CONCLUSION:
TGF-beta1 may be one of the most important factors in the regulation of the infiltrate, and in the production of tissue repair with a stimulation of fibroblasts and endothelial cells.
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Authors | Roberto Cornelini, Corrado Rubini, Massimiliano Fioroni, Gian Antonio Favero, Rita Strocchi, Adriano Piattelli |
Journal | Journal of periodontology
(J Periodontol)
Vol. 74
Issue 4
Pg. 446-50
(Apr 2003)
ISSN: 0022-3492 [Print] United States |
PMID | 12747448
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Dental Implants
- TGFB1 protein, human
- Transforming Growth Factor beta
- Transforming Growth Factor beta1
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Topics |
- Adult
- Dental Implants
(adverse effects)
- Dental Restoration Failure
- Endothelium
(blood supply, cytology, metabolism)
- Female
- Gingiva
(blood supply, metabolism)
- Gingivitis
(etiology, metabolism)
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Mouth Mucosa
(blood supply, metabolism)
- Statistics, Nonparametric
- Transforming Growth Factor beta
(biosynthesis, physiology)
- Transforming Growth Factor beta1
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