Alcohol metabolism: role in toxicity and carcinogenesis.

Abstract

This article contains the proceedings of a symposium at the 2002 RSA Meeting in San Francisco, organized and co-chaired by Thomas M. Badger, Paul Shih-Jiun Yin, and Helmut Seitz. The presentations were (1) First-pass metabolism of ethanol: Basic and clinical aspects, by Charles Lieber; (2) Intracellular CYP2E1 transport, oxidative stress, cytokine release, and ALD, by Magnus Ingelman-Sundberg; (3) Pulsatile ethanol metabolism in intragastric infusion models: Potential role in toxic outcomes, by Thomas M. Badger and Martin J.J. Ronis; (4) Free radicals, adducts, and autoantibodies resulting from ethanol metabolism: Role in ethanol-associated toxicity, by Emanuele Albano; and (5) Gastrointestinal metabolism of ethanol and its possible role in carcinogenesis, by Helmut Seitz.

• Authors: Thomas M Badger, Martin J J Ronis, Helmut K Seitz, Emanuele Albano, Magnus Ingelman-Sundberg, Charles S Lieber
• Journal: Alcoholism, clinical and experimental research (Alcohol Clin Exp Res) Vol. 27 Issue 2 Pg. 336-47 (Feb 2003) ISSN: 0145-6008 [Print] England
• PMID: 12605083 (Publication Type: Congress, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Cytokines
• Ethanol
• Alcohol Dehydrogenase
• Cytochrome P-450 CYP2E1

Topics

• Alcohol Dehydrogenase (genetics, physiology)
• Alcoholic Intoxication (enzymology)
• Animals
• Cytochrome P-450 CYP2E1 (genetics, physiology)
• Cytokines (blood)
• Ethanol (pharmacokinetics, toxicity)
• Gastrointestinal Neoplasms (enzymology, etiology)
• Humans
• Oxidative Stress (physiology)
• Polymorphism, Genetic (genetics)
• Risk Factors