[Transarterial intrahepatic xenotransplantation of microencapsulated newborn porcine islets--an experimental study of type 1 diabetes mellitus].

Abstract

OBJECTIVE:

To evaluate the physiologic features and probable side effects of transarterial intrahepatic xenotransplantation of microencapsulated newborn porcine islets.

METHODS:

Six artificial diabetic canines were transplanted intrahepatically with 6-9 x 10(5) encapsulated newborn porcine islets without immunosuppression. Before and after the transplantation, the serum C peptide, glucose tolerance test, and dosage of insulin were measured. Samples of the livers and pancreases were examined pathologically 6 months after the operation.

RESULTS:

After the transplantation of microencapsulated porcine islets, the serum C peptides were elevated significantly. The plasma glucose returned to normal gradually. The dosage of insulin decreased. Six months after the operation, the usage of insulin in 2 dogs was stopped and the normal plasma glucose was kept for 180 days. The pathologic examination showed the xenografts located in the interlobular artery of the livers and the livers of canines were not damaged.

CONCLUSION:

The transplantation may correct the high plasma glucose level of diabetic canines without immunosuppression and has no side reactions.

• Authors: Bin Ye, Wei Wang, Sheng Liu
• Journal: Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University (Hunan Yi Ke Da Xue Xue Bao) Vol. 27 Issue 1 Pg. 4-8 (Feb 28 2002) ISSN: 1000-5625 [Print] China
• PMID: 12575218 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Animals
• Animals, Newborn
• Diabetes Mellitus, Experimental (surgery)
• Diabetes Mellitus, Type 1 (surgery)
• Dogs
• Drug Compounding
• Female
• Hepatic Artery
• Islets of Langerhans Transplantation
• Male
• Swine
• Transplantation, Heterologous