Abstract | BACKGROUND: METHODS: We investigated the relationship between childhood abuse and HPA axis function using a combined dexamethasone/CRH (DEX/CRH) test in 39 BPD patients with (n = 24) and without (n = 15) sustained childhood abuse and comorbid PTSD (n = 12) or MDD (n = 11) and 11 healthy control subjects. RESULTS: Chronically abused BPD patients had a significantly enhanced corticotropin ( ACTH) and cortisol response to the DEX/CRH challenge compared with nonabused subjects. Comorbid PTSD significantly attenuated the ACTH response. CONCLUSIONS: Hyperresponsiveness of the HPA axis in chronically abused BPD subjects might be due to the enhanced central drive to pituitary ACTH release. Sustained childhood abuse rather than BPD, MDD, or PTSD pathology accounts for this effect. Possibly due to an enhanced efficacy of HPA suppression by dexamethasone, PTSD attenuates the ACTH response to DEX/CRH.
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Authors | Thomas Rinne, E Ronald de Kloet, Luuk Wouters, Jaap G Goekoop, Roel H DeRijk, Wim van den Brink |
Journal | Biological psychiatry
(Biol Psychiatry)
Vol. 52
Issue 11
Pg. 1102-12
(Dec 01 2002)
ISSN: 0006-3223 [Print] United States |
PMID | 12460693
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Dexamethasone
- Adrenocorticotropic Hormone
- Corticotropin-Releasing Hormone
- Hydrocortisone
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Topics |
- Adolescent
- Adrenocorticotropic Hormone
(blood)
- Adult
- Borderline Personality Disorder
(physiopathology, psychology)
- Case-Control Studies
- Child Abuse
- Corticotropin-Releasing Hormone
- Dexamethasone
- Female
- Humans
- Hydrocortisone
(blood)
- Hypothalamo-Hypophyseal System
(physiopathology)
- Middle Aged
- Pituitary-Adrenal System
(physiopathology)
- Stress Disorders, Post-Traumatic
(psychology)
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