[Risk factors in adult periodontitis: polymorphism in the interleukin-1 gene family].

Abstract

Interleukin (IL)-1 alpha, IL-1 beta and IL-1 receptor antagonist (ra) play a major role in regulation of the inflammatory response in periodontal tissues. The aim of this study was to investigate the distribution of genetic variation in the IL-1 gene family among periodontitis patients and controls, taking into account smoking and microbiology as additional variables. There were 53 non-smoking and 52 smoking patients with severe adult periodontitis and 53 periodontal healthy controls genotyped for genetic variation in the IL-1 gene family. The presence of Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans was established by culture techniques. A higher frequency of genotype+ (IL-1A*2 + IL-1B*2 + IL-1RN*2) was found in non-smoking periodontitis patients in whom P. gingivalis and A. actinomycetemcomitans could not be detected (42.1% vs. 11.3% in controls; p = 0.0068; or 5.7, 95% ci: 1.6-19.8). This data provide evidence that polymorphisms in genes of the IL-1 family are associated with severe adult periodontitis and may be a risk factor for severe periodontitis.

• Authors: M L Laine, M A Farré, M A García-González, L J van Dijk, A J Ham, E G Winkel, J B A Crusius, J P Vandenbroucke, A J van Winkelhoff, A S Peña
• Journal: Nederlands tijdschrift voor tandheelkunde (Ned Tijdschr Tandheelkd) Vol. 109 Issue 8 Pg. 303-6 (Aug 2002) ISSN: 0028-2200 [Print] Netherlands
• Vernacular Title: Risicofactoren voor adulte parodontitis: polymorfismen in de interleukine-1 genfamilie.
• PMID: 12212456 (Publication Type: Journal Article)

Chemical References

• Interleukin-1

Topics

• Adult
• Aggregatibacter actinomycetemcomitans (pathogenicity, physiology)
• Female
• Genetic Variation
• Humans
• Interleukin-1 (genetics)
• Male
• Middle Aged
• Periodontitis (genetics, microbiology)
• Polymorphism, Genetic
• Porphyromonas gingivalis (pathogenicity, physiology)
• Risk Factors
• Smoking