The influence of
L-arginine (600 mg/kg) and
NO-synthase blocator
N omega-nitro-L-arginine L-NNA (35 mg/kg) on processes of
ADP-stimulated respiration (under using 0.35 mM
succinate, 1 mM
alpha-ketoglutarate, 2 mM
pyruvate, 2 mM
glutamate, 2 Mm
malate and
succinate dehydrohenase blocator--2 mM
malonate as substrates of oxidation), lipid peroxidation (concentration of DK and MDA), activities of
succinate dehydrohenase and
aminotransferases in rats tissues with different resistance to
hypoxia under stress conditions have been investigated. It have been shown that the energy metabolism indices (respiration rate and efficiency of phosphorilation
ADP/O) are higher in high resistent (HR) animals in the control group. Stress causes the increase of
ADP-stimulated respiration in low resistent (LR) under
succinate oxidation and decrease of
NADPH-dependent utilization, indicative of more effort of energy system in LR animals. Stress conditions are connected with the increase of lipid peroxidation products in blood both in LR and in HR animals, though in hepar their concentration change unimportantly. Injection of
L-arginine decreases aerobic component of energy metabolism on the background decreasing
aminotransferases ways of oxidation and
succinate dehydrohenase activity.
L-arginine causes decrease of lipid peroxidation products in LR, in HR the same effect reaches by L-NNA injection. The has been made conclusion about tight correlation between energy metabolism, processes of lipid peroxidation with resistance to
hypoxia and functioning of
nitric oxide cycle under stress conditions.