Abstract | BACKGROUND:
Nitric oxide (NO) production is increased among patients with human immunodeficiency virus ( HIV) infection and also those with tuberculosis (TB). In this study we sought to determine if there was increased NO production among patients with HIV/TB coinfection and the effect of four weeks chemotherapy on this level. PATIENTS AND METHODS: RESULTS: Mean age of HIV/TB patients was 28.4+6.8 years and CD4 count was 116+36.6/mm3. Mean nitrite level among HIV/TB coinfected was 207.6+48.8 nmol/ml. This was significantly higher than 99.7+26.5 nmol/ml, the value for HIV infected without opportunistic infections and 46.4+16.2 nmol/ml, the value for healthy controls (p value <0.01). Level of HIV/TB coinfected declined to 144.5+ 34.4 nmol/ml at four weeks of therapy (p value < 0.05). Mean citrulline among HIV/TB coinfected was 1446.8+468.8 nmol/ml. This was significantly higher than 880.8+ 434.8 nmol/ml, the value for HIV infected without opportunistic infections and 486.6+212.5 nmol/ml, the value for healthy controls (p value <0.01). Levels of HIV/TB infected declined to 1116.2+388.6 nmol/ml at four weeks of therapy (p value <0.05). CONCLUSION: NO production is elevated among patients with HIV infection, especially so among HIV/TB coinfected, but declines significantly following 4 weeks of antitubercular therapy.
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Authors | Ajay Wanchu, Archana Bhatnagar, Madhu Khullar, Archana Sud, Pradeep Bambery, Surjit Singh |
Journal | BMC infectious diseases
(BMC Infect Dis)
Vol. 2
Pg. 15
(Jul 29 2002)
ISSN: 1471-2334 [Electronic] England |
PMID | 12147177
(Publication Type: Journal Article)
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Chemical References |
- Antibiotics, Antitubercular
- Antitubercular Agents
- Biomarkers
- Enzyme Inhibitors
- Nitrites
- Citrulline
- Pyrazinamide
- Nitric Oxide
- Ethambutol
- Isoniazid
- Rifampin
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Topics |
- Adult
- Antibiotics, Antitubercular
(pharmacology, therapeutic use)
- Antitubercular Agents
(therapeutic use)
- Biomarkers
(blood)
- CD4 Lymphocyte Count
- CD4-Positive T-Lymphocytes
(metabolism)
- Citrulline
(blood)
- Drug Administration Schedule
- Enzyme Inhibitors
(therapeutic use)
- Ethambutol
(therapeutic use)
- Female
- HIV Infections
(drug therapy, immunology, metabolism)
- Humans
- Isoniazid
(therapeutic use)
- Male
- Middle Aged
- Mycobacterium
(drug effects)
- Nitric Oxide
(antagonists & inhibitors, biosynthesis)
- Nitrites
(blood)
- Pyrazinamide
(therapeutic use)
- Rifampin
(therapeutic use)
- T-Lymphocyte Subsets
(metabolism)
- Tuberculosis
(drug therapy, immunology, metabolism)
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